Gopal Kundu

Gopal Chandra Kundu (born 1959) is an renowned Indian cell and cancer biologist and a Senior Scientist (Scientist-G) at National Centre for Cell Science.[1] He is known for his contributions towards the understanding the mechanism of cancer progression in breast, melanoma and other cancers and development of novel therapeutic targets and target-based therapy in cancers.[2]

Gopal Kundu
Born (1959-11-02) 2 November 1959
Bataspur, West Bengal
NationalityIndian
Known forTherapeutics; Biomarker (cell); Angiogenesis; Nanomedicine;
AwardsN-BIOS Prize, Shanti Swarup Bhatnagar Prize for Science and Technology
Scientific career
FieldsCancer
InstitutionsNational Centre for Cell Science

An elected fellow of the Indian Academy of Sciences[3] and the National Academy of Sciences, India,[4] he received the National Bioscience Award for Career Development of the Department of Biotechnology in 2003.[5] The Council of Scientific and Industrial Research, the apex agency of the Government of India for scientific research, awarded him the Shanti Swarup Bhatnagar Prize for Science and Technology, one of the highest Indian science awards, in 2004, for his contributions to biological sciences.[6]

Education and career

Kundu obtained his Ph.D. from Bose Institute, Kolkata, India (1989) in protein biochemistry and did his post-doctoral research work at the Cleveland Clinic Foundation, University of Colorado, University of Wyoming, and the National Institutes of Health from 1989 to 1998. He has performed work in the area of cardiovascular biology, inflammation and immunomodulation during that period. In 1998, he joined as Scientist-D at the National Centre for Cell Science (NCCS), Pune.[7] At present, he is working as Scientist-G at NCCS. His area of research at NCCS is tumor biology, regulation of gene expression, cell signaling, angiogenesis, cancer therapeutics, biomarker studies for cancer detection, and nanomedicine.[8][9]

He is Fellow of The National Academy of Sciences, India, and Indian Academy of Sciences. He is member of American Society for Biochemistry and Molecular Biology and New York Academy of Sciences. He has published 70 papers in peer reviewed international journals.

He serves as Editorial Board Member of Current Molecular Medicine, Molecular Medicine Reports, The Open Cancer Journal and American Journal of Cancer Research.

Awards

In 2004 Kundu was awarded a Shanti Swarup Bhatnagar Prize for Science and Technology,[10][11] following the receipt of an earlier National Bioscience Award for Career Development in 2003.[11] International Journal of Oncology, Oncology Reports and International Journal of Molecular Medicine Award for an outstanding achievement in Oncology, Greece; International Young Investigator Award, USA. 7th National Grassroots Innovation Award-2013, Rashtrapati Bhavan, New Delhi.

Controversy

A controversy erupted in the NCCS in 2006 when an anonymous mail alleged that Kundu and others might have misrepresented data in a paper published in the Journal of Biological Chemistry. The allegation was that they had rehashed the same set of data which they had published earlier.[12] An internal committee of the NCCS advised the authors to take back their paper, however an independent committee led by G. Padmanabhan, a former director of Indian Institute of Science, Bangalore, concluded that there was no manipulation in the data.[13] This led to some heated debate between Indian Scientists with several viewpoints being presented.[14][15] On 23 February 2007, the Journal of Biological Chemistry withdrew the paper amid allegations of data manipulation, although the authors maintained that the two papers used different set of data though similar experiments. One JBC paper was retracted by JBC [16] because they found the data to be unreliable.[17] In November 2010, after an internal investigation by its ethics committee, the Indian Academy of Sciences banned Gopal Kundu from participating in its activities for three years.[18]

Selected publications
  • Philip, S; Bulbule, A; Kundu, GC (2001). "Osteopontin stimulates tumor growth and activation of pro-matrix metalloproteinase-2 through NF-kappa B mediated induction of membrane type 1-matrix metalloproteinase in murine melanoma cells". J. Biol. Chem. 276 (48): 44926–44935. doi:10.1074/jbc.m103334200. PMID 11564733.
  • Mahabeleshwar, GH; Kundu, GC (2003). "Syk, a protein tyrosine kinase, suppresses the cell motility and NF-kappa B mediated secretion of urokinase type plasminogen activator by inhibiting the phosphatidylinositol 3'-kinase activity in breast cancer cells". J. Biol. Chem. 278 (8): 6209–6221. doi:10.1074/jbc.m208905200. PMID 12477728.
  • Philip, S; Kundu, GC (2003). "Osteopontin induces NF-kappa B mediated promatrix metalloproteinase-2 activation through IKK/IκBα signaling pathways and curcumin (diferulolylmethane) down regulates these pathways". J. Biol. Chem. 278 (16): 14487–14497. doi:10.1074/jbc.m207309200. PMID 12473670.
  • Das, R; Mahabeleshwar, GH; Kundu, GC (2003). "Osteopontin stimulates cell motility and NF-kB mediated secretion of urokinase type plasminogen activator through phosphatidylinositol 3-kinase/Akt signaling pathways in breast cancer cells". J. Biol. Chem. 278 (31): 28593–28606. doi:10.1074/jbc.m303445200. PMID 12771144.
  • Mahabeleshwar, GH; Kundu, GC (2003). "Tyrosine kinase, p56lck regulates cell motility and NF-kB-mediated secretion of urokinase type plasminogen activator through tyrosine phosphorylation of IkBa following hypoxia/reoxygenation". J. Biol. Chem. 278 (52): 52598–52612. doi:10.1074/jbc.m308941200. PMID 14534291.
  • Mahabeleshwar, GH; Das, R; Kundu, GC (2004). "Tyrosine kinase, p56lck-induced cell motility and urokinase type plasminogen activator secretion involves activation of epidermal growth factor receptor/extracellular signal regulated kinase pathways". J. Biol. Chem. 279 (11): 9733–9742. doi:10.1074/jbc.m311400200.
  • Das, R; Mahabeleshwar, GH; Kundu, GC (2004). "Osteopontin induces AP-1-mediated secretion of urokinase type plasminogen activator through c-Src dependent EGF receptor transactivation in breast cancer cells". J. Biol. Chem. 279 (12): 11051–11064. doi:10.1074/jbc.m310256200. PMID 14704150.
  • Rangaswami, H; Bulbule, A; Kundu, GC (2004). "Nuclear factor inducing kinase plays crucial role in osteopontin induced MAPK/IKK dependent nuclear factor kB-mediated promatrix metalloproteinase-9 activation". J. Biol. Chem. 279 (37): 38921–38935. doi:10.1074/jbc.m404674200. PMID 15247285.
  • Rangaswami, H; Bulbule, A; Kundu, GC (2006). "Osteopontin: role in cell signaling and cancer progression". Trends Cell Biol. 16 (2): 79–87. doi:10.1016/j.tcb.2005.12.005. PMID 16406521.
  • Chakraborty, G; Rangaswami, R; Jain, S; Kundu, GC (2006). "Hypoxia regulates crosstalk between Syk and Lck leading to breast cancer progression and angiogenesis". J. Biol. Chem. 281 (16): 11322–11331. doi:10.1074/jbc.m512546200. PMID 16474166.
  • Jain, S; Chakraborty, G; Kundu, GC (2006). "The Crucial Role of cyclooxygenase-2 in osteopontin-induced PKCα/c-Src/IKKα/β dependent prostate tumor progression and angiogenesis". Cancer Research. 66 (13): 6638–6648. doi:10.1158/0008-5472.can-06-0661. PMID 16818637.
  • Chakraborty, G; Jain, S; Kundu, GC (2008). "Osteopontin promotes VEGF dependent breast tumor growth and angiogenesis via autocrine and paracrine mechanisms". Cancer Research. 68 (1): 152–161. doi:10.1158/0008-5472.can-07-2126. PMID 18172307.
  • Jain, S; Chakraborty, G; Raja, R; Kale, S; Kundu, GC (2008). "Prostaglandin E2 regulates tumor angiogenesis in prostate cancer". Cancer Research. 68 (19): 7750–7759. doi:10.1158/0008-5472.can-07-6689. PMID 18829529.
  • Behera, R; Kumar, V; Lohite, K; Karnik, S; Kundu, GC (2010). "Activation of JAK2/STAT3 signaling by osteopontin promotes tumor growth in human breast cancer cells". Carcinogenesis. 31 (2): 192–200. doi:10.1093/carcin/bgp289. PMID 19926637.
  • Ahmed, M; Kundu, GC (2010). "Osteopontin selectively regulates p70S6K/mTOR phosphorylation leading to NF-kappa B dependent AP-1-mediated ICAM-1 expression in breast cancer cells". Molecular Cancer. 9 (1): 101. doi:10.1186/1476-4598-9-101. PMC 2881115. PMID 20459645.
  • Sharma, P; Kumar, S; Kundu, GC (2010). "Transcriptional regulation of human osteopontin promoter by histone deacetylase inhibitor, trichostatin A in cervical cancer cells". Molecular Cancer. 9 (1): 178. doi:10.1186/1476-4598-9-178. PMC 2911447. PMID 20609221.
  • Kumar, V; Behera, R; Lohite, K; Karnik, S; Kundu, GC (2010). "p38 Kinase is Crucial for Osteopontin-induced Furin Expression that Supports Cervical Cancer Progression". Cancer Research. 70 (24): 10381–10391. doi:10.1158/0008-5472.can-10-1470. PMID 20980434.
  • Panda, JJ; Kaul, A; Kumar, S; Alam, S; Mishra, AK; Kundu, GC; Chauhan, VS (2013). "Modified dipeptide-based nanoparticles: vehicles for targeted tumor drug delivery". Nanomedicine (Lond.). 8 (12): 1927–42. doi:10.2217/nnm.12.201. PMID 23398497.
  • Raja, R; Kale, S; Thorat, D; Gowrishankar, S; Lohite, K; Mane, A; Karnik, S; Kundu, GC (2013). "Hypoxia driven osteopontin contributes to breast tumor growth through modulation of HIF1α-mediated VEGF dependent angiogenesis". Oncogene. 33 (16): 2053–2064. doi:10.1038/onc.2013.171. PMID 23728336.
  • Kale, S; Raja, R; Thorat, D; Gowrishankar, S; Patil, TV; Kundu, GC (2013). "Osteopontin signaling upregulates cyclooxygenase-2 expression in tumor-associated macrophages leading to enhanced angiogenesis and melanoma growth via α9β1 integrin". Oncogene. 33 (18): 2295–2306. doi:10.1038/onc.2013.184.
  • Mishra, R; Thorat, D; Soundararajan, G; Pradhan, SJ; Chakraborty, G; Lohite, K; Karnik, S; Kundu, GC (March 2015). "Semaphorin 3A upregulates FOXO 3a-dependent MelCAM expression leading to attenuation of breast tumor growth and angiogenesis". Oncogene. 34 (12): 1584–95. doi:10.1038/onc.2014.79. PMID 24727891.
  • Ghosh, S; Adhikary, A; Chakraborty, S; Bhattacharjee, P; Mazumder, M; Putatunda, S; Gorain, M; Chakraborty, A; Kundu, GC; Das, T; Sen, PC (February 2015). "Cross-talk between endoplasmic reticulum (ER) stress and the MEK/ERK pathway potentiates apoptosis in human triple negative breast carcinoma cells: role of a dihydropyrimidone, nifetepimine". J Biol Chem. 290 (7): 3936–49. doi:10.1074/jbc.M114.594028. PMC 4326803. PMID 25527500.
  • Mishra, R; Kumar, D; Tomar, D; Chakraborty, G; Kumar, S; Kundu, GC (March 2015). "The potential of class 3 semaphorins as both targets and therapeutics in cancer". Expert Opin Ther Targets. 19 (3): 427–42. doi:10.1517/14728222.2014.986095. PMID 25434284.
  • Nanjappa, V; Renuse, S; Sathe, GJ; Raja, R; Syed, N; Radhakrishnan, A; Subbannayya, T; Patil, A; Marimuthu, A; Sahasrabuddhe, NA; Guerrero-Preston, R; Somani, BL; Nair, B; Kundu, GC; Prasad, TK; Califano, JA; Gowda, H; Sidransky, D; Pandey, A; Chatterjee, A (October 2015). "Chronic exposure to chewing tobacco selects for overexpression of stearoyl-CoA desaturase in normal oral keratinocytes". Cancer Biol Ther. 16 (11): 1593–603. doi:10.1080/15384047.2015.1078022. PMC 4846103. PMID 26391970.
  • Ghosh, S; More, P; Derle, A; Kitture, R; Kale, T; Gorain, M; Avasthi, A; Markad, P; Kundu, GC; Kale, S; Dhavale, DD; Bellare, J; Chopade, BA (December 2015). "Diosgenin Functionalized Iron Oxide Nanoparticles as Novel Nanomaterial Against Breast Cancer". J Nanosci Nanotechnol. 15 (12): 9464–72. doi:10.1166/jnn.2015.11704. PMID 26682367.
  • Rustagi, Y; Jaiswal, HK; Rawal, K; Kundu, GC; Rani, V (October 2015). "Comparative Characterization of Cardiac Development Specific microRNAs: Fetal Regulators for Future". PLOS ONE. 10 (10): e0139359. doi:10.1371/journal.pone.0139359. PMC 4605649. PMID 26465880.
  • Mukherjee, Shravanti; Manna, Argha; Bhattacharjee, Pushpak; Mazumdar, Minakshi; Saha, Shilpi; Chakraborty, Samik; Guha, Deblina; Adhikary, Arghya; Jana, Debarshi; Gorain, Mahadeo; Mukherjee, Sanhita; Kundu, G. C.; Sarkar, Diptendra; Das, Tanya (February 2016). "Non-migratory tumorigenic intrinsic cancer stem cells ensure breast cancer metastasis by generation of CXCR4+ migrating cancer stem cells". Oncogene. 35 (37): 4937–4948. doi:10.1038/onc.2016.26. PMID 26923331.
  • Kumar, Dhiraj; Kumar, Santosh; Gorain, Mahadeo; Tomar, Deepti; Patil, Harshal S.; Radharani, NNV; Kumar, TVS; Patil, Tushar V.; Thulasiram, H. V.; Kundu, G. C. (2016). "Notch1-MAPK Signaling Axis Regulates CD133+ Cancer Stem Cell-Mediated Melanoma Growth and Angiogenesis". Journal of Investigative Dermatology. 136 (12): 2462–2474. doi:10.1016/j.jid.2016.07.024. PMID 27476721.
  • Dai, Xiaoyun; Ahn, Kwang Seok; Wang, Ling Zhi; Kim, Chulwon; Deivasigamni, Amudha; Arfuso, Frank; Um, Jae-Young; Kumar, Alan Prem; Chang, Young-Chae; Kumar, Dhiraj; Kundu, Gopal C; Magae, Junji; Goh, Boon Cher; Hui, Kam Man; Sethi, Gautam (2016). "Ascochlorin Enhances the Sensitivity of Doxorubicin Leading to the Reversal of Epithelial-to-Mesenchymal Transition in Hepatocellular Carcinoma". Molecular Cancer Therapeutics. 15 (12): 2966–2976. doi:10.1158/1535-7163.MCT-16-0391. PMID 27765853.
  • Kumar, Dhiraj; Gorain, Mahadeo; Kundu, Gautam; Kundu, Gopal C (2017). "Therapeutic implications of cellular and molecular biology of cancer stem cells in melanoma". Molecular Cancer. 16 (1): 7. doi:10.1186/s12943-016-0578-3. PMC 5282877. PMID 28137308.
  • Ghosh, Alip; Dasgupta, Debanjali; Ghosh, Amit; Roychoudhury, Shrabasti; Kumar, Dhiraj; Gorain, Mahadeo; Butti, Ramesh; Datta, Simanti; Agarwal, Shaleen; Gupta, Subash; Krishna Dhali, Gopal; Chowdhury, Abhijit; Schmittgen, Thomas D; Kundu, Gopal C; Banerjee, Soma (2017). "MiRNA199a-3p suppresses tumor growth, migration, invasion and angiogenesis in hepatocellular carcinoma by targeting VEGFA, VEGFR1, VEGFR2, HGF and MMP2". Cell Death & Disease. 8 (3): e2706. doi:10.1038/cddis.2017.123. PMC 5386529. PMID 28358369.
  • Wadhwani, Sweety; Gorain, Mahadeo; Banerjee, Pinaki; Shedbalkar, Utkarsha; Singh, Richa; Kundu, Gopal; Chopade, Balu A (2017). "Green synthesis of selenium nanoparticles using Acinetobacter sp. SW30: Optimization, characterization and its anticancer activity in breast cancer cells". International Journal of Nanomedicine. 12: 6841–6855. doi:10.2147/IJN.S139212. PMC 5602452. PMID 28979122.
  • Datta, Arindam; Ghatak, Dishari; Das, Sumit; Banerjee, Taraswi; Paul, Anindita; Butti, Ramesh; Gorain, Mahadeo; Ghuwalewala, Sangeeta; Roychowdhury, Anirban; Alam, Sk Kayum; Das, Pijush; Chatterjee, Raghunath; Dasgupta, Maitrayee; Panda, Chinmay Kumar; Kundu, Gopal C; Roychoudhury, Susanta (2017). "P53 gain‐of‐function mutations increase Cdc7‐dependent replication initiation". EMBO Reports. 18 (11): 2030–2050. doi:10.15252/embr.201643347. PMC 5666604. PMID 28887320.

See also

References
  1. "Brief Profile of the Awardee". Shanti Swarup Bhatnagar Prize. 2016. Retrieved 5 October 2016.
  2. "Handbook of Shanti Swarup Bhatnagar Prize Winners" (PDF). Council of Scientific and Industrial Research. 1999. p. 34. Archived from the original (PDF) on 4 March 2016. Retrieved 5 October 2016.
  3. "Fellow profile - G C Kundu". Indian Academy of Sciences. 2016. Retrieved 6 October 2016.
  4. "NASI fellows". National Academy of Sciences, India. 2016. Archived from the original on 15 March 2016. Retrieved 20 October 2016.
  5. "N-BIOS Prize" (PDF). Department of Biotechnology. 2016. Retrieved 20 October 2016.
  6. "View Bhatnagar Awardees". Shanti Swarup Bhatnagar Prize. 2016. Retrieved 5 October 2016.
  7. "Dr. Gopal Kundu". NCCS. 1 January 2001. Archived from the original on 27 September 2011. Retrieved 8 November 2011.
  8. "DBT neurobiology task force". Neurobiology. 5 March 2004.
  9. "Curriculum vitae". apoptosis. 20 August 2005. Archived from the original on 25 April 2012. Retrieved 9 November 2011.
  10. "PM presents Bhatnagar prizes to 21 scientists". The Times of India. 29 September 2005.
  11. "Two Pune scientists bag Bhatnagar prize". The Times of India. 29 September 2004.
  12. "Kundu-JBC Case". Society for Scientific Values.
  13. G.S. mudur (6 March 2007). "Indicted there, acquitted here". The Telegraph. Calcutta, India.
  14. S.P. Modak (10 June 2007). "Investigating Misconduct in Science" (PDF). Current Science. 92 (11).
  15. G. Padmanabhan (10 June 2007). "The NCCS Case" (PDF). Current Science. 92 (11).
  16. "JNK1 differentially regulates osteopontin-induced nuclear factor-inducing kinase/MEKK1-dependent activating protein-1-mediated promatrix metalloproteinase-9 activation". J. Biol. Chem. 282 (8): 5968. 2007. PMID 17380579.
  17. Hema Rangaswami (12 September 2007). "'Coping with misconduct in Indian science': a response". The Hindu. Chennai, India.
  18. Jayan, T.V. (14 November 2010). "'Rehashing catches up - Once-acquitted biologist barred for 3 years'". The Telegraph. Kolkata, India.
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