Glycine formimidoyltransferase
In enzymology, a glycine formimidoyltransferase (EC 2.1.2.4) is an enzyme that catalyzes the chemical reaction
- 5-formimidoyltetrahydrofolate + glycine tetrahydrofolate + N-formimidoylglycine
| glycine formimidoyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 2.1.2.4 | ||||||||
| CAS number | 9029-84-9 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Thus, the two substrates of this enzyme are 5-formimidoyltetrahydrofolate and glycine, whereas its two products are tetrahydrofolate and N-formimidoylglycine.
This enzyme belongs to the family of transferases that transfer one-carbon groups, specifically the hydroxymethyl-, formyl- and related transferases. The systematic name of this enzyme class is 5-formimidoyltetrahydrofolate:glycine N-formimidoyltransferase. Other names in common use include formiminoglycine formiminotransferase, FIG formiminotransferase, and glycine formiminotransferase. This enzyme participates in purine metabolism and one carbon pool by folate.
References
- Rabinowitz JC; Pricer WE (1956). "Formiminotetrahydrofolic acid and methenyltetrahydrofolic acid as intermediates in the formation of N10-formyltetrahydrofolic acid". J. Am. Chem. Soc. 78 (21): 5702–5704. doi:10.1021/ja01602a073.
- Rabinowitz JC; Pricer WE (1957). "Formation, isolation and properties of 5-formiminotetrahydrofolic acid". Fed. Proc. 16: 236.
- Sagers RD, Beck JV, Gruber W, Gunsalus IC (1956). "A tetrahydrofolic acid linked formimino transfer enzyme". J. Am. Chem. Soc. 78: 694–695. doi:10.1021/ja01584a054.
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