Glycine dehydrogenase (cyanide-forming)
In enzymology, a glycine dehydrogenase (cyanide-forming) (EC 1.4.99.5) is an enzyme that catalyzes the chemical reaction
- glycine + 2 A hydrogen cyanide + CO2 + 2 AH2
| glycine dehydrogenase (cyanide-forming) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 1.4.99.5 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Thus, the two substrates of this enzyme are glycine and A, whereas its 3 products are hydrogen cyanide, CO2, and AH2.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH2 group of donors with other acceptors. The systematic name of this enzyme class is glycine:acceptor oxidoreductase (hydrogen-cyanide-forming). Other names in common use include hydrogen cyanide synthase, and HCN synthase.
References
- Wissing F (1975). "Cyanide production from glycine by a homogenate from a Pseudomonas species". J. Bacteriol. 121 (2): 695–9. PMC 245984. PMID 234422.
- Castric PA (1977). "Glycine metabolism by Pseudomonas aeruginosa: hydrogen cyanide biosynthesis". J. Bacteriol. 130 (2): 826–31. PMC 235287. PMID 233722.
- Haas D; Blumer, C; Von Schroetter, C; Gaia, V; Défago, G; Keel, C; Haas, D (1998). "Characterization of the hcnABC gene cluster encoding hydrogen cyanide synthase and anaerobic regulation by ANR in the strictly aerobic biocontrol agent Pseudomonas fluorescens CHA0". J. Bacteriol. 180 (12): 3187–96. PMC 107821. PMID 9620970.
- Blumer C, Haas D (2000). "Mechanism, regulation, and ecological role of bacterial cyanide biosynthesis". Arch. Microbiol. 173 (3): 170–7. doi:10.1007/s002039900127. PMID 10763748.
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