Glycine/sarcosine N-methyltransferase

Glycine/sarcosine N-methyltransferase (EC 2.1.1.156, ApGSMT, glycine-sarcosine methyltransferase, GSMT, GMT, glycine sarcosine N-methyltransferase, S-adenosyl-L-methionine:sarcosine N-methyltransferase) is an enzyme with systematic name S-adenosyl-L-methionine:glycine(or sarcosine) N-methyltransferase (sarcosine(or N,N-dimethylglycine)-forming).[1][2][3] This enzyme catalyses the following chemical reaction

2 S-adenosyl-L-methionine + glycine 2 S-adenosyl-L-homocysteine + N,N-dimethylglycine (overall reaction)
(1a) S-adenosyl-L-methionine + glycine S-adenosyl-L-homocysteine + sarcosine
(1b) S-adenosyl-L-methionine + sarcosine S-adenosyl-L-homocysteine + N,N-dimethylglycine
Glycine/sarcosine N-methyltransferase
Identifiers
EC number2.1.1.156
CAS number294210-82-5
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

This enzyme participates in biosynthesis of betaine from glycine in cyanobacterium Aphanocthece halophytica.

References

  1. Nyyssola A, Kerovuo J, Kaukinen P, von Weymarn N, Reinikainen T (July 2000). "Extreme halophiles synthesize betaine from glycine by methylation". The Journal of Biological Chemistry. 275 (29): 22196–201. doi:10.1074/jbc.M910111199. PMID 10896953.
  2. Nyyssölä A, Reinikainen T, Leisola M (May 2001). "Characterization of glycine sarcosine N-methyltransferase and sarcosine dimethylglycine N-methyltransferase". Applied and Environmental Microbiology. 67 (5): 2044–50. doi:10.1128/AEM.67.5.2044-2050.2001. PMC 92834. PMID 11319079.
  3. Waditee R, Tanaka Y, Aoki K, Hibino T, Jikuya H, Takano J, Takabe T, Takabe T (February 2003). "Isolation and functional characterization of N-methyltransferases that catalyze betaine synthesis from glycine in a halotolerant photosynthetic organism Aphanothece halophytica". The Journal of Biological Chemistry. 278 (7): 4932–42. doi:10.1074/jbc.M210970200. PMID 12466265.
This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.