Glutathione amide reductase

Glutathione amide reductase (EC 1.8.1.16, GAR) is an enzyme with systematic name glutathione amide:NAD+ oxidoreductase.[1][2] This enzyme catalyses the following chemical reaction

2 glutathione amide + NAD+ glutathione amide disulfide + NADH + H+
Glutathione amide reductase
Identifiers
EC number1.8.1.16
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

Glutathione amide reductase is a dimeric flavoprotein (FAD).

References

  1. Vergauwen B, Pauwels F, Jacquemotte F, Meyer TE, Cusanovich MA, Bartsch RG, Van Beeumen JJ (June 2001). "Characterization of glutathione amide reductase from Chromatium gracile. Identification of a novel thiol peroxidase (Prx/Grx) fueled by glutathione amide redox cycling". The Journal of Biological Chemistry. 276 (24): 20890–7. doi:10.1074/jbc.M102026200. PMID 11399772.
  2. Vergauwen B, Van Petegem F, Remaut H, Pauwels F, Van Beeumen JJ (February 2002). "Crystallization and preliminary X-ray crystallographic analysis of glutathione amide reductase from Chromatium gracile". Acta Crystallographica Section D. 58 (Pt 2): 339–40. doi:10.1107/s0907444901020303. PMID 11807270.
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