Galactosylceramide sulfotransferase
In enzymology, a galactosylceramide sulfotransferase (EC 2.8.2.11) is an enzyme that catalyzes the chemical reaction
- 3'-phosphoadenylyl sulfate + a galactosylceramide adenosine 3',5'-bisphosphate + a galactosylceramidesulfate
| galactosylceramide sulfotransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 2.8.2.11 | ||||||||
| CAS number | 9081-06-5 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Thus, the two substrates of this enzyme are 3'-phosphoadenylyl sulfate and galactosylceramide, whereas its two products are adenosine 3',5'-bisphosphate and galactosylceramidesulfate.
This enzyme belongs to the family of transferases, specifically the sulfotransferases, which transfer sulfur-containing groups. The systematic name of this enzyme class is 3'-phosphoadenylyl-sulfate:galactosylceramide 3'-sulfotransferase. Other names in common use include GSase, 3'-phosphoadenosine-5'-phosphosulfate-cerebroside sulfotransferase, galactocerebroside sulfotransferase, galactolipid sulfotransferase, glycolipid sulfotransferase, and glycosphingolipid sulfotransferase. This enzyme participates in sphingolipid metabolism.
References
- McKhann GM, Levy R, Ho W (1965). "Metabolism of sulfatides. I. The effect of galactocerebrosides on the synthesis of sulfatides". Biochem. Biophys. Res. Commun. 20 (2): 109–13. doi:10.1016/0006-291X(65)90331-1. PMID 5850675.
- Sakakibara N, Gasa S, Kamio K, Makita A, Koyanagi T (1989). "Association of elevated sulfatides and sulfotransferase activities with human renal cell carcinoma". Cancer Res. 49 (2): 335–9. PMID 2562926.