Galactitol-1-phosphate 5-dehydrogenase

In enzymology, a galactitol-1-phosphate 5-dehydrogenase (EC 1.1.1.251) is an enzyme that catalyzes the chemical reaction

galactitol-1-phosphate + NAD+ L-tagatose 6-phosphate + NADH + H+
galactitol-1-phosphate 5-dehydrogenase
Identifiers
EC number1.1.1.251
CAS number167618-25-9
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

Thus, the two substrates of this enzyme are galactitol-1-phosphate and NAD+, whereas its 3 products are L-tagatose 6-phosphate, NADH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is galactitol-1-phosphate:NAD+ oxidoreductase. This enzyme participates in galactose metabolism. It employs one cofactor, zinc.

References

    • Nobelmann B, Lengeler JW (1995). "Sequence of the gat operon for galactitol utilization from a wild-type strain EC3132 of Escherichia coli". Biochim. Biophys. Acta. 1262 (1): 69–72. doi:10.1016/0167-4781(95)00053-j. PMID 7772602.


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