GABRG3

GABAA receptor-γ3, also known as GABRG3, is a protein which in humans is encoded by the GABRG3 gene.

GABRG3
Identifiers
AliasesGABRG3, gamma-aminobutyric acid type A receptor gamma3 subunit, gamma-aminobutyric acid type A receptor subunit gamma3
External IDsOMIM: 600233 MGI: 95624 HomoloGene: 22444 GeneCards: GABRG3
Gene location (Human)
Chr.Chromosome 15 (human)[1]
Band15q12Start26,971,181 bp[1]
End27,541,984 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

2567

14407

Ensembl

ENSG00000182256

ENSMUSG00000055026

UniProt

Q99928

P27681

RefSeq (mRNA)

NM_001270873
NM_033223

NM_008074
NM_177273

RefSeq (protein)

NP_001257802
NP_150092

NP_032100

Location (UCSC)Chr 15: 26.97 – 27.54 MbChr 7: 56.72 – 57.39 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

GABRG3 is a subunit of the GABAA receptor for the neurotransmitter gamma-Aminobutyric acid (GABA).[5]

Association with alcoholism

Genetic markers near the GABRG3 gene are statistically linked to alcoholism.[6]

See also

References
  1. GRCh38: Ensembl release 89: ENSG00000182256 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000055026 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: GABRG3 gamma-aminobutyric acid (GABA) A receptor, gamma 3".
  6. Dick DM, Edenberg HJ, Xuei X, Goate A, Kuperman S, Schuckit M, Crowe R, Smith TL, Porjesz B, Begleiter H, Foroud T (January 2004). "Association of GABRG3 with alcohol dependence". Alcohol. Clin. Exp. Res. 28 (1): 4–9. CiteSeerX 10.1.1.418.2528. doi:10.1097/01.ALC.0000108645.54345.98. PMID 14745296.

Further reading
  • Greger V, Knoll JH, Woolf E, et al. (1995). "The gamma-aminobutyric acid receptor gamma 3 subunit gene (GABRG3) is tightly linked to the alpha 5 subunit gene (GABRA5) on human chromosome 15q11-q13 and is transcribed in the same orientation". Genomics. 26 (2): 258–264. doi:10.1016/0888-7543(95)80209-5. PMID 7601451.
  • Tögel M, Mossier B, Fuchs K, Sieghart W (1994). "gamma-Aminobutyric acidA receptors displaying association of gamma 3-subunits with beta 2/3 and different alpha-subunits exhibit unique pharmacological properties". J. Biol. Chem. 269 (17): 12993–12998. PMID 8175718.
  • Hadingham KL, Wafford KA, Thompson SA, et al. (1996). "Expression and pharmacology of human GABAA receptors containing gamma 3 subunits". Eur. J. Pharmacol. 291 (3): 301–309. doi:10.1016/0922-4106(95)90070-5. PMID 8719414.
  • Poulsen CF, Christjansen KN, Hastrup S, Hartvig L (2000). "Identification and cloning of a gamma 3 subunit splice variant of the human GABA(A) receptor". Brain Res. Mol. Brain Res. 78 (1–2): 201–203. doi:10.1016/S0169-328X(00)00085-1. PMID 10891602.
  • Harrington JJ, Sherf B, Rundlett S, et al. (2001). "Creation of genome-wide protein expression libraries using random activation of gene expression". Nat. Biotechnol. 19 (5): 440–445. doi:10.1038/88107. PMID 11329013.
  • Nymann-Andersen J, Wang H, Chen L, et al. (2002). "Subunit specificity and interaction domain between GABA(A) receptor-associated protein (GABARAP) and GABA(A) receptors". J. Neurochem. 80 (5): 815–823. doi:10.1046/j.0022-3042.2002.00762.x. PMID 11948245.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Dick DM, Edenberg HJ, Xuei X, et al. (2004). "Association of GABRG3 with alcohol dependence". Alcohol. Clin. Exp. Res. 28 (1): 4–9. CiteSeerX 10.1.1.418.2528. doi:10.1097/01.ALC.0000108645.54345.98. PMID 14745296.
  • Gole L, Crolla JA, Thomas SN, et al. (2004). "Characterization of breakpoints in the GABRG3 and TSPY genes in a family with a t(Y;15)(p11.2;q12)". Am. J. Med. Genet. A. 125 (2): 177–180. doi:10.1002/ajmg.a.20482. PMID 14981720.

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