Fructose 5-dehydrogenase (NADP+)

In enzymology, a fructose 5-dehydrogenase (NADP+) (EC 1.1.1.124) is an enzyme that catalyzes the chemical reaction

D-fructose + NADP+ 5-dehydro-D-fructose + NADPH + H+
fructose 5-dehydrogenase (NADP+)
Identifiers
EC number1.1.1.124
CAS number37250-53-6
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

Thus, the two substrates of this enzyme are D-fructose and NADP+, whereas its 3 products are 5-dehydro-D-fructose, NADPH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is D-fructose:NADP+ 5-oxidoreductase. Other names in common use include 5-ketofructose reductase (NADP+), 5-keto-D-fructose reductase (NADP+), fructose 5-(nicotinamide adenine dinucleotide phosphate), dehydrogenase, D-(-)fructose:(NADP+) 5-oxidoreductase, and fructose 5-dehydrogenase (NADP+).

References

    • Ameyama M, Matsushita K, Shinagawa E, Adachi O (1981). "5-keto-D-Fructose reductase of Gluconobacter industrius Purification, crystallization and properties". Agric. Biol. Chem. 45 (4): 863–869. doi:10.1271/bbb1961.45.863.
    • Avigad G, Englard S, Pifko S (1966). "5-Keto-D-fructose. IV. A specific reduced nicotinamide adenine dinucleotide phosphate-linked reductase from Gluconobacter cerinus". J. Biol. Chem. 241 (2): 373–8. PMID 4379259.


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