Fosfluconazole
Fosfluconazole (INN) is a water-soluble phosphate prodrug of fluconazole[1] — a triazole antifungal drug used in the treatment and prevention of superficial and systemic fungal infections.[2]
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Routes of administration | IV |
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Formula | C13-H13-F2-N6-O4-P |
Molar mass | 386.25 g/mol |
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The phosphate ester bond is hydrolyzed by the action of a phosphatase — an enzyme that removes a phosphate group from its substrate by hydrolyzing phosphoric acid monoesters into a phosphate ion and a molecule with a free hydroxyl group (dephosphorylation).
References
- Bentley, Arthur; Butters, Michael; Green, Stuart P.; Learmonth, William J.; MacRae, Julie A.; Morland, Matthew C.; O'Conno, Garry; Skuse, Joanne (2002). "The Discovery and Process Development of a Commercial Route to the Water Soluble Prodrug, Fosfluconazole". Organic Process Research & Development. 6 (2): 109–112. doi:10.1021/op010064+. ISSN 1083-6160.
- Takahashi, Daijiro; Nakamura, Tomohiko; Shigematsu, Reiko; Matsui, Miyu; Araki, Shunsuke; Kubo, Kazuyasu; Sato, Hiroshi; Shirahata, Akira (2009-05-25). "Fosfluconazole for Antifungal Prophylaxis in Very Low Birth Weight Infants". International Journal of Pediatrics. 2009 (2009): 274768. doi:10.1155/2009/274768. PMC 2778452. PMID 19946419.
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