FZR1

FZR1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4UI9
Identifiers
Aliases	FZR1, CDC20C, CDH1, FZR, FZR2, HCDH, HCDH1, fizzy/cell division cycle 20 related 1, fizzy and cell division cycle 20 related 1
External IDs	OMIM: 603619 MGI: 1926790 HomoloGene: 9444 GeneCards: FZR1
Gene location (Human)
Chr.	Chromosome 19 (human)[1]
End	3,538,330 bp[1]
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)[2]
End	81,378,516 bp[2]
RNA expression pattern
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	• GO:0001948 protein binding; • anaphase-promoting complex binding; • ubiquitin-protein transferase activator activity;
Cellular component	• cytoplasm; • cytosol; • nuclear membrane; • nucleoplasm; • anaphase-promoting complex; • cell nucleus;
Biological process	• positive regulation of protein catabolic process; • negative regulation of cell aging; • regulation of meiotic nuclear division; • cellular response to DNA damage stimulus; • cell division; • protein K11-linked ubiquitination; • lens fiber cell differentiation; • protein ubiquitination; • positive regulation of cell proliferation; • cell cycle; • anaphase-promoting complex-dependent catabolic process; • DNA repair; • positive regulation of ubiquitin protein ligase activity; • signal transduction involved in G2 DNA damage checkpoint; • regulation of mitotic cell cycle phase transition; • ubiquitin-dependent protein catabolic process;
	Sources:Amigo / QuickGO
Orthologs
	51343
	56371
	ENSG00000105325
	ENSMUSG00000020235
	Q9UM11
	Q9R1K5
	NM_001136197; NM_001136198; NM_016263
	NM_019757
	NP_001129669; NP_001129670; NP_057347
	NP_062731
	Wikidata
View/Edit Human	View/Edit Mouse

Fizzy-related protein homolog, also known as hCDH1, is a protein that in humans is encoded by the FZR1 gene.[5][6][7][8]

Interactions

FZR1 has been shown to interact with CDC27[9][10] and FBXO5.[11]

References

GRCh38: Ensembl release 89: ENSG00000105325 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000020235 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Kramer, Edgar R.; Gieffers, Christian; Hölzl, Gabriele; Hengstschläger, Markus; Peters, Jan-Michael (1998-11-05). "Activation of the human anaphase-promoting complex by proteins of the CDC20/Fizzy family". Current Biology. 8 (22): 1207–S4. doi:10.1016/S0960-9822(07)00510-6. ISSN 0960-9822. PMID 9811605.
Fang G, Yu H, Kirschner MW (August 1998). "Direct binding of CDC20 protein family members activates the anaphase-promoting complex in mitosis and G1". Molecular Cell. 2 (2): 163–71. doi:10.1016/S1097-2765(00)80126-4. PMID 9734353.
Sorensen CS, Lukas C, Kramer ER, Peters JM, Bartek J, Lukas J (October 2000). "Nonperiodic activity of the human anaphase-promoting complex-Cdh1 ubiquitin ligase results in continuous DNA synthesis uncoupled from mitosis". Molecular and Cellular Biology. 20 (20): 7613–23. doi:10.1128/MCB.20.20.7613-7623.2000. PMC 86321. PMID 11003657.
"Entrez Gene: FZR1 fizzy/cell division cycle 20 related 1 (Drosophila)".
Zhou Y, Ching YP, Ng RW, Jin DY (September 2003). "Differential expression, localization and activity of two alternatively spliced isoforms of human APC regulator CDH1". The Biochemical Journal. 374 (Pt 2): 349–58. doi:10.1042/BJ20030600. PMC 1223613. PMID 12797865.
Kramer ER, Gieffers C, Hölzl G, Hengstschläger M, Peters JM (November 1998). "Activation of the human anaphase-promoting complex by proteins of the CDC20/Fizzy family". Current Biology. 8 (22): 1207–10. doi:10.1016/S0960-9822(07)00510-6. PMID 9811605.
Hsu JY, Reimann JD, Sørensen CS, Lukas J, Jackson PK (May 2002). "E2F-dependent accumulation of hEmi1 regulates S phase entry by inhibiting APC(Cdh1)". Nature Cell Biology. 4 (5): 358–66. doi:10.1038/ncb785. PMID 11988738.

External links

Overview of all the structural information available in the PDB for UniProt: Q9UM11 (Fizzy-related protein homolog) at the PDBe-KB.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000105325 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000020235 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] Kramer, Edgar R.; Gieffers, Christian; Hölzl, Gabriele; Hengstschläger, Markus; Peters, Jan-Michael (1998-11-05). "Activation of the human anaphase-promoting complex by proteins of the CDC20/Fizzy family". Current Biology. 8 (22): 1207–S4. doi:10.1016/S0960-9822(07)00510-6. ISSN 0960-9822. PMID 9811605.

[pmid9734353-6] Fang G, Yu H, Kirschner MW (August 1998). "Direct binding of CDC20 protein family members activates the anaphase-promoting complex in mitosis and G1". Molecular Cell. 2 (2): 163–71. doi:10.1016/S1097-2765(00)80126-4. PMID 9734353.

[pmid11003657-7] Sorensen CS, Lukas C, Kramer ER, Peters JM, Bartek J, Lukas J (October 2000). "Nonperiodic activity of the human anaphase-promoting complex-Cdh1 ubiquitin ligase results in continuous DNA synthesis uncoupled from mitosis". Molecular and Cellular Biology. 20 (20): 7613–23. doi:10.1128/MCB.20.20.7613-7623.2000. PMC 86321. PMID 11003657.

[entrez-8] "Entrez Gene: FZR1 fizzy/cell division cycle 20 related 1 (Drosophila)".

[pmid12797865-9] Zhou Y, Ching YP, Ng RW, Jin DY (September 2003). "Differential expression, localization and activity of two alternatively spliced isoforms of human APC regulator CDH1". The Biochemical Journal. 374 (Pt 2): 349–58. doi:10.1042/BJ20030600. PMC 1223613. PMID 12797865.

[pmid9811605-10] Kramer ER, Gieffers C, Hölzl G, Hengstschläger M, Peters JM (November 1998). "Activation of the human anaphase-promoting complex by proteins of the CDC20/Fizzy family". Current Biology. 8 (22): 1207–10. doi:10.1016/S0960-9822(07)00510-6. PMID 9811605.

[pmid11988738-11] Hsu JY, Reimann JD, Sørensen CS, Lukas J, Jackson PK (May 2002). "E2F-dependent accumulation of hEmi1 regulates S phase entry by inhibiting APC(Cdh1)". Nature Cell Biology. 4 (5): 358–66. doi:10.1038/ncb785. PMID 11988738.

FZR1

Interactions

References

Further reading

External links