FBXO5

F-box only protein 5 is a protein that in humans is encoded by the FBXO5 gene.[5][6][7]

FBXO5
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesFBXO5, EMI1, FBX5, Fbxo31, F-box protein 5
External IDsOMIM: 606013 MGI: 1914391 HomoloGene: 8135 GeneCards: FBXO5
Gene location (Human)
Chr.Chromosome 6 (human)[1]
Band6q25.2Start152,970,519 bp[1]
End152,983,579 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

26271

67141

Ensembl

ENSG00000112029

ENSMUSG00000019773

UniProt

Q9UKT4

Q7TSG3

RefSeq (mRNA)

NM_001142522
NM_012177

NM_025995

RefSeq (protein)

NP_001135994
NP_036309

NP_080271

Location (UCSC)Chr 6: 152.97 – 152.98 MbChr 10: 5.8 – 5.81 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. This protein is similar to xenopus early mitotic inhibitor-1 (Emi1), which is a mitotic regulator that interacts with Cdc20 and inhibits the anaphase promoting complex.[7] Moreover, Emi1 also assembles a CRL1 complex that targets RAD51 for ubiquitin-mediated degradation.[8]

Disease

Gene and protein expression of FBXO5/Emi1 are increased in many human cancers and increased expression has been shown to cause chromosome instability and cancer.[9]

Interactions

FBXO5 has been shown to interact with:

References
  1. GRCh38: Ensembl release 89: ENSG00000112029 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000019773 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Cenciarelli C, Chiaur DS, Guardavaccaro D, Parks W, Vidal M, Pagano M (October 1999). "Identification of a family of human F-box proteins". Current Biology. 9 (20): 1177–9. doi:10.1016/S0960-9822(00)80020-2. PMID 10531035.
  6. Winston JT, Koepp DM, Zhu C, Elledge SJ, Harper JW (October 1999). "A family of mammalian F-box proteins". Current Biology. 9 (20): 1180–2. doi:10.1016/S0960-9822(00)80021-4. PMID 10531037.
  7. "Entrez Gene: FBXO5 F-box protein 5".
  8. Marzio A, Puccini J, Kwon Y, Maverakis NK, Arbini A, Sung P, et al. (January 2019). "The F-Box Domain-Dependent Activity of EMI1 Regulates PARPi Sensitivity in Triple-Negative Breast Cancers". Molecular Cell. 73 (2): 224–237.e6. doi:10.1016/j.molcel.2018.11.003. PMC 6995265. PMID 30554948.
  9. Vaidyanathan S, Cato K, Tang L, Pavey S, Haass NK, Gabrielli BG, Duijf PH (October 2016). "In vivo overexpression of Emi1 promotes chromosome instability and tumorigenesis". Oncogene. 35 (41): 5446–5455. doi:10.1038/onc.2016.94. PMID 27065322.
  10. Hsu JY, Reimann JD, Sørensen CS, Lukas J, Jackson PK (May 2002). "E2F-dependent accumulation of hEmi1 regulates S phase entry by inhibiting APC(Cdh1)". Nature Cell Biology. 4 (5): 358–66. doi:10.1038/ncb785. PMID 11988738.
  11. Cenciarelli C, Chiaur DS, Guardavaccaro D, Parks W, Vidal M, Pagano M (October 1999). "Identification of a family of human F-box proteins". Current Biology. 9 (20): 1177–9. doi:10.1016/S0960-9822(00)80020-2. PMID 10531035.

Further reading
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