FGD2

FGD2
Identifiers
Aliases	FGD2, ZFYVE4, FYVE, RhoGEF and PH domain containing 2
External IDs	OMIM: 605091 MGI: 1347084 HomoloGene: 8438 GeneCards: FGD2
Gene location (Human)
Chr.	Chromosome 6 (human)[1]
End	37,029,069 bp[1]
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)[2]
End	29,379,661 bp[2]
Gene ontology
Molecular function	• phosphatidylinositol phosphate binding; • metal ion binding; • small GTPase binding; • GO:0001948 protein binding; • guanyl-nucleotide exchange factor activity; • Rho guanyl-nucleotide exchange factor activity;
Cellular component	• cytoplasm; • cytosol; • endosome; • Golgi apparatus; • cell projection; • early endosome membrane; • membrane; • ruffle; • cell membrane; • ruffle membrane; • early endosome; • cytoskeleton; • cell nucleus; • lamellipodium;
Biological process	• positive regulation of JUN kinase activity; • regulation of GTPase activity; • filopodium assembly; • cytoskeleton organization; • regulation of cell shape; • positive regulation of apoptotic process; • regulation of Rho protein signal transduction; • regulation of small GTPase mediated signal transduction; • actin cytoskeleton organization; • G-protein coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	221472
	26382
	ENSG00000146192
	ENSMUSG00000024013
	Q7Z6J4
	Q8BY35
	NM_173558
	NM_001159538; NM_013710
	NP_775829
	NP_001153010; NP_038738
	Wikidata
View/Edit Human	View/Edit Mouse

FYVE, RhoGEF and PH domain-containing protein 2 (FGD2), also known as zinc finger FYVE domain-containing protein 4 (ZFYVE4), is a protein that in humans is encoded by the FGD2 gene.[5]

It is a member of the FYVE, RhoGEF and PH domain containing family.

References

GRCh38: Ensembl release 89: ENSG00000146192 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000024013 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: FYVE".

Salehi AH, Xanthoudakis S, Barker PA (2002). "NRAGE, a p75 neurotrophin receptor-interacting protein, induces caspase activation and cell death through a JNK-dependent mitochondrial pathway". J. Biol. Chem. 277 (50): 48043–50. doi:10.1074/jbc.M205324200. PMID 12376548.
Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
Hattori A, Okumura K, Nagase T, et al. (2000). "Characterization of long cDNA clones from human adult spleen". DNA Res. 7 (6): 357–66. doi:10.1093/dnares/7.6.357. PMID 11214971.
Pasteris NG, Gorski JL (1999). "Isolation, characterization, and mapping of the mouse and human Fgd2 genes, faciogenital dysplasia (FGD1; Aarskog syndrome) gene homologues". Genomics. 60 (1): 57–66. doi:10.1006/geno.1999.5903. PMID 10458911.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Harrington AW, Kim JY, Yoon SO (2002). "Activation of Rac GTPase by p75 is necessary for c-jun N-terminal kinase-mediated apoptosis". J. Neurosci. 22 (1): 156–66. doi:10.1523/JNEUROSCI.22-01-00156.2002. PMC 6757583. PMID 11756498.
Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Rabizadeh S, Bredesen DE (2003). "Ten years on: mediation of cell death by the common neurotrophin receptor p75(NTR)". Cytokine Growth Factor Rev. 14 (3–4): 225–39. doi:10.1016/S1359-6101(03)00018-2. PMID 12787561.
Huber C, Mårtensson A, Bokoch GM, et al. (2008). "FGD2, a CDC42-specific exchange factor expressed by antigen-presenting cells, localizes to early endosomes and active membrane ruffles". J. Biol. Chem. 283 (49): 34002–12. doi:10.1074/jbc.M803957200. PMC 2590680. PMID 18838382.
Delague V, Jacquier A, Hamadouche T, et al. (2007). "Mutations in FGD4 encoding the Rho GDP/GTP exchange factor FRABIN cause autosomal recessive Charcot-Marie-Tooth type 4H". Am. J. Hum. Genet. 81 (1): 1–16. doi:10.1086/518428. PMC 1950914. PMID 17564959.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000146192 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000024013 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: FYVE".

FGD2

References

Further reading