Dolichyl-phosphatase
In enzymology, a dolichyl-phosphatase (EC 3.1.3.51) is an enzyme that catalyzes the chemical reaction
- dolichyl phosphate + H2O dolichol + phosphate
| dolichyl-phosphatase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 3.1.3.51 | ||||||||
| CAS number | 72994-50-4 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Thus, the two substrates of this enzyme are dolichyl phosphate and H2O, whereas its two products are dolichol and phosphate.
This enzyme belongs to the family of hydrolases, to be specific, those acting on phosphoric monoester bonds. The systematic name of this enzyme class is dolichyl-phosphate phosphohydrolase. Other names in common use include dolichol phosphate phosphatase, dolichol phosphatase, dolichol monophosphatase, dolichyl monophosphate phosphatase, dolichyl phosphate phosphatase, polyisoprenyl phosphate phosphatase, polyprenylphosphate phosphatase, and Dol-P phosphatase. This enzyme participates in n-glycan biosynthesis.
References
- Adrian GS, Keenan RW (1979). "A dolichyl phosphate-cleaving acid phosphatase from Tetrahymena pyriformis". Biochim. Biophys. Acta. 575 (3): 431–8. doi:10.1016/0005-2760(79)90112-7. PMID 229909.
- Rip JW, Rupar CA, Chaudhary N, Carroll KK (1981). "Localization of a dolichyl phosphate phosphatase in plasma membranes of rat liver". J. Biol. Chem. 256 (4): 1929–34. PMID 6257694.
- Wedgwood JF, Strominger JL (1980). "Enzymatic activities in cultured human lymphocytes that dephosphorylate dolichyl pyrophosphate and dolichyl phosphate". J. Biol. Chem. 255 (3): 1120–3. PMID 6243292.
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