Dihydrocarveol dehydrogenase
Dihydrocarveol dehydrogenase (EC 1.1.1.296, carveol dehydrogenase (ambiguous)) is an enzyme with systematic name menth-8-en-2-ol:NAD+ oxidoreductase.[1] This enzyme catalyses the following chemical reaction
- menth-8-en-2-ol + NAD+ menth-8-en-2-one + NADH + H+
| Dihydrocarveol dehydrogenase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 1.1.1.296 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
This enzyme from the Gram-positive bacterium Rhodococcus erythropolis DCL14 forms part of the carveol and dihydrocarveol degradation pathway. The enzyme accepts all eight stereoisomers of menth-8-en-2-ol as substrate, although some isomers are converted faster than others. The preferred substrates are (+)-neoisodihydrocarveol, (+)-isodihydrocarveol, (+)-dihydrocarveol and (-)-isodihydrocarveol.
References
- van der Werf MJ, Boot AM (May 2000). "Metabolism of carveol and dihydrocarveol in Rhodococcus erythropolis DCL14". Microbiology. 146 ( Pt 5): 1129–41. doi:10.1099/00221287-146-5-1129. PMID 10832640.
External links
- Dihydrocarveol+dehydrogenase at the US National Library of Medicine Medical Subject Headings (MeSH)
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