Demethylmacrocin O-methyltransferase

In enzymology, a demethylmacrocin O-methyltransferase (EC 2.1.1.102) is an enzyme that catalyzes the chemical reaction

S-adenosyl-L-methionine + demethylmacrocin S-adenosyl-L-homocysteine + macrocin
demethylmacrocin O-methyltransferase
Identifiers
EC number2.1.1.102
CAS number120313-64-6
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

Thus, the two substrates of this enzyme are S-adenosyl methionine and demethylmacrocin, whereas its two products are S-adenosylhomocysteine and macrocin.

This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:demethylmacrocin 2"'-O-methyltransferase. This enzyme is also called demethylmacrocin methyltransferase. This enzyme participates in biosynthesis of 12-, 14- and 16-membered macrolides.

References

    • Kreuzman AJ, Turner JR, Yeh WK (1988). "Two distinctive O-methyltransferases catalyzing penultimate and terminal reactions of macrolide antibiotic (tylosin) biosynthesis Substrate specificity, enzyme inhibition, and kinetic mechanism". J. Biol. Chem. 263 (30): 15626–33. PMID 3170602.


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