Delta8-fatty-acid desaturase
Delta8-fatty-acid desaturase (EC 1.14.19.4, Delta8-sphingolipid desaturase, EFD1, BoDES8, SLD, Delta8 fatty acid desaturase, Delta8-desaturase) is an enzyme with systematic name phytosphinganine,hydrogen donor:oxygen Delta8-oxidoreductase.[1][2][3][4] This enzyme catalyses the following chemical reaction
- phytosphinganine + reduced acceptor + O2 Delta8-phytosphingenine + acceptor + 2 H2O
| Delta8-fatty-acid desaturase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 1.14.19.4 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
This enzyme, which has been found mainly in plants, introduces a double bond at Delta8 of C18 and C20 fatty acids.
References
- Wallis JG, Browse J (May 1999). "The Delta8-desaturase of Euglena gracilis: an alternate pathway for synthesis of 20-carbon polyunsaturated fatty acids". Archives of Biochemistry and Biophysics. 365 (2): 307–16. doi:10.1006/abbi.1999.1167. PMID 10328826.
- Sperling P, Libisch B, Zähringer U, Napier JA, Heinz E (April 2001). "Functional identification of a delta8-sphingolipid desaturase from Borago officinalis". Archives of Biochemistry and Biophysics. 388 (2): 293–8. doi:10.1006/abbi.2001.2308. PMID 11368168.
- Takakuwa N, Kinoshita M, Oda Y, Ohnishi M (December 2002). "Isolation and characterization of the genes encoding delta(8)-sphingolipid desaturase from Saccharomyces kluyveri and Kluyveromyces lactis". Current Microbiology. 45 (6): 459–61. doi:10.1007/s00284-002-3860-0. PMID 12402089.
- Beckmann C, Rattke J, Oldham NJ, Sperling P, Heinz E, Boland W (July 2002). "Characterization of a Delta8-sphingolipid desaturase from higher plants: a stereochemical and mechanistic study on the origin of E,Z isomers". Angewandte Chemie. 41 (13): 2298–300. doi:10.1002/1521-3773(20020703)41:13<2298::AID-ANIE2298>3.0.CO;2-G. PMID 12203571.
External links
- Delta8-fatty-acid+desaturase at the US National Library of Medicine Medical Subject Headings (MeSH)
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