D-arabinose 1-dehydrogenase

In enzymology, a D-arabinose 1-dehydrogenase (EC 1.1.1.116) is an enzyme that catalyzes the chemical reaction

D-arabinose + NAD+ D-arabinono-1,4-lactone + NADH + H+
D-arabinose 1-dehydrogenase
Identifiers
EC number1.1.1.116
CAS number37250-47-8
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

Thus, the two substrates of this enzyme are D-arabinose and NAD+, whereas its 3 products are D-arabinono-1,4-lactone, NADH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is D-arabinose:NAD+ 1-oxidoreductase. Other names in common use include NAD+-pentose-dehydrogenase, and arabinose(fucose)dehydrogenase.

References

    • Palleroni NJ; Doudoroff M (1957). "Metabolism of carbohydrates by Pseudomonas saccharophilla. III Oxidation of D-arabinose". J. Bacteriol. 74 (2): 180–185. PMC 289912. PMID 13475218.
    • Schiwara HW, Domschke W, Domagk GF (1968). "Über die Zucker-Dehydrogenasen in der Säugetierleber, I. Differenzierung verschiedener Zucker-Dehydrogenasen in der Schweineleber durch Disk-Elektrophorese und Ionenaustauschchromatographie" [Sugar dehydrogenases in mammalian liver. I. Differentiation of various sugar dehydrogenases from pig liver by disc electrophoresis and ion exchange chromatography]. Hoppe-Seyler's Z. Physiol. Chem. (in German). 349 (11): 1575–81. doi:10.1515/bchm2.1968.349.2.1575. PMID 4393642.


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