Cyclohexanol dehydrogenase

In enzymology, a cyclohexanol dehydrogenase (EC 1.1.1.245) is an enzyme that catalyzes the chemical reaction

cyclohexanol + NAD+ cyclohexanone + NADH + H+
cyclohexanol dehydrogenase
Identifiers
EC number1.1.1.245
CAS number63951-98-4
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

Thus, the two substrates of this enzyme are cyclohexanol and NAD+, whereas its 3 products are cyclohexanone, NADH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is cyclohexanol:NAD+ oxidoreductase. This enzyme participates in caprolactam degradation.

References

    • Dangel W, Tschech A, Fuchs G (1989). "Enzyme-reactions involved in anaerobic cyclohexanol metabolism by a denitrifying Pseudomonas species". Arch. Microbiol. 152 (3): 273–279. doi:10.1007/BF00409663. PMID 2505723.
    • Donoghue NA, Trudgill PW (1975). "The metabolism of cyclohexanol by Acinetobacter NCIB 9871". Eur. J. Biochem. 60 (1): 1–7. doi:10.1111/j.1432-1033.1975.tb20968.x. PMID 1261.
    • Trower MK, Buckland RM, Higgins R, Griffin M (1985). "Isolation and Characterization of a Cyclohexane-Metabolizing Xanthobacter sp". Appl. Environ. Microbiol. 49 (5): 1282–1289. PMC 238543. PMID 16346796.


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