Cyclohexane-1,2-diol dehydrogenase

In enzymology, a cyclohexane-1,2-diol dehydrogenase (EC 1.1.1.174) is an enzyme that catalyzes the chemical reaction

trans-cyclohexane-1,2-diol + NAD+ 2-hydroxycyclohexan-1-one + NADH + H+
cyclohexane-1,2-diol dehydrogenase
Identifiers
EC number1.1.1.174
CAS number62628-27-7
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

Thus, the two substrates of this enzyme are trans-cyclohexane-1,2-diol and NAD+, whereas its 3 products are 2-hydroxycyclohexan-1-one, NADH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is trans-cyclohexane-1,2-diol:NAD+ 1-oxidoreductase. This enzyme participates in caprolactam degradation.

References

    • Davey JF, Trudgill PW (1977). "The metabolism of trans-cyclohexan-1,2-diol by an Acinetobacter species". Eur. J. Biochem. 74 (1): 115–27. doi:10.1111/j.1432-1033.1977.tb11373.x. PMID 856571.


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