Cyclamate sulfohydrolase

In enzymology, a cyclamate sulfohydrolase (EC 3.10.1.2) is an enzyme that catalyzes the chemical reaction

cyclohexylsulfamate + H2O cyclohexylamine + sulfate
cyclamate sulfohydrolase
Identifiers
EC number3.10.1.2
CAS number52228-00-9
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

Thus, the two substrates of this enzyme are cyclohexylsulfamate and H2O, whereas its two products are cyclohexylamine and sulfate.

This enzyme belongs to the family of hydrolases, specifically those acting on sulfur-nitrogen bonds. The systematic name of this enzyme class is cyclohexylsulfamate sulfohydrolase. Other names in common use include cyclamate sulfamatase, cyclamate sulfamidase, and cyclohexylsulfamate sulfamidase. This enzyme participates in caprolactam degradation.

References

    • Nimura T, Tokieda T, Yamaha T (February 1974). "Partial purification and some properties of cyclamate sulfamatase". J. Biochem. Tokyo. 75 (2): 407–17. PMID 4209783.


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