Codeinone reductase (NADPH)
In enzymology, a codeinone reductase (NADPH) (EC 1.1.1.247) is an enzyme that catalyzes the chemical reaction
- codeine + NADP+ codeinone + NADPH + H+
| codeinone reductase (NADPH) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 1.1.1.247 | ||||||||
| CAS number | 153302-41-1 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Thus, the two substrates of this enzyme are codeine and NADP+, whereas its 3 products are codeinone, NADPH, and H+.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is codeine:NADP+ oxidoreductase. This enzyme participates in alkaloid biosynthesis i.
References
- Lenz R; Zenk MH (1995). "Stereoselective reduction of codeinone, the penultimate step during morphine biosynthesis in Papaver somniferum". Tetrahedron Lett. 36 (14): 2449–2452. doi:10.1016/0040-4039(95)00278-K.
- Lenz R, Zenk MH (1995). "Purification and properties of codeinone reductase (NADPH) from Papaver somniferum cell cultures and differentiated plants". Eur. J. Biochem. 233 (1): 132–9. doi:10.1111/j.1432-1033.1995.132_1.x. PMID 7588736.
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