Codeine 3-O-demethylase
Codeine 3-O-demethylase (EC 1.14.11.32, codeine O-demethylase, CODM) is an enzyme with systematic name codeine,2-oxoglutarate:oxygen oxidoreductase (3-O-demethylating).[1] This enzyme catalyses the following chemical reaction
- codeine + 2-oxoglutarate + O2 morphine + formaldehyde + succinate + CO2
| Codeine 3-O-demethylase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 1.14.11.32 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Codeine 3-O-demethylase contains Fe2+.
References
- Hagel JM, Facchini PJ (April 2010). "Dioxygenases catalyze the O-demethylation steps of morphine biosynthesis in opium poppy". Nature Chemical Biology. 6 (4): 273–5. doi:10.1038/nchembio.317. PMID 20228795.
External links
- Codeine+3-O-demethylase at the US National Library of Medicine Medical Subject Headings (MeSH)
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