Chlorohydroxyphenylglycine

Chlorohydroxyphenylglycine
Names
	IUPAC name Amino(2-chloro-5-hydroxyphenyl)acetic acid
Identifiers
CAS Number	170846-74-9 ; 1303993-73-8 (sodium salt) ;
3D model (JSmol)	Interactive image;
Abbreviations	CHPG
ChemSpider	2879711;
ECHA InfoCard	100.162.133
IUPHAR/BPS	1417;
PubChem CID	3645780;
CompTox Dashboard (EPA)	DTXSID60394614 ;
	InChI InChI=1S/C8H8ClNO3/c9-6-2-1-4(11)3-5(6)7(10)8(12)13/h1-3,7,11H,10H2,(H,12,13) Key: UNIDAFCQFPGYJJ-UHFFFAOYSA-N; InChI=1/C8H8ClNO3/c9-6-2-1-4(11)3-5(6)7(10)8(12)13/h1-3,7,11H,10H2,(H,12,13) Key: UNIDAFCQFPGYJJ-UHFFFAOYAM;
	SMILES Clc1ccc(O)cc1C(N)C(=O)O;
Properties
Chemical formula	C8H6ClNO3
Molar mass	199.59 g·mol−1
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
	Infobox references

2-Chloro-5-hydroxyphenylglycine or CHPG is an agonist of the metabotropic glutamate receptors, specific for mGluR5.[1]

It is capable of directly potentiating the depolarization of hippocampal CA1 neurons induced through NMDA administration.[2]

References

Kammermeier, Paul J (2012). "The orthosteric agonist 2-chloro-5-hydroxyphenylglycine activates mGluR5 and mGluR1 with similar efficacy and potency". BMC Pharmacology. 12: 6. doi:10.1186/1471-2210-12-6. PMC 3416681. PMID 22642439.
Collingridge G.; Volianskis A.; Bannister N.; France G.; Hanna L.; Mercier M.; Tidball P.; Fang G.; Irvine M.; Costa, Blaise M.; Monaghan, Daniel T.; Bortolotto, Zuner A.; Molnár, Elek; Lodge, David; Jane, David E. (2013). "The NMDA receptor as a target for cognitive enhancement". Neuropharmacology. 64: 13–26. doi:10.1016/j.neuropharm.2012.06.051. PMC 4696548. PMID 22796429.

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