Charles Sawyers

Charles L. Sawyers is a Howard Hughes Medical Institute (HHMI) investigator who holds the Marie-Josée and Henry R. Kravis Chair of the Human Oncology and Pathogenesis Program (HOPP) at Memorial Sloan Kettering Cancer Center (MSK). HOPP is a program created in 2006 that comprises researchers from many disciplines to bridge clinical and laboratory discoveries.[2]

Charles L. Sawyers
Born
Charles Lazelle Sawyers[1]

1959 (age 60–61)
Nashville, Tennessee
EducationJohns Hopkins University, Princeton, UCSF
Medical career
ProfessionPhysician
InstitutionsMemorial Sloan Kettering Cancer Center
Howard Hughes Medical Institute
ResearchLeukemia/prostate cancer
AwardsLasker Clinical Award (2009)
BBVA Foundation Frontiers of Knowledge Award (2014)

Career

Sawyers received a BA from Princeton University in 1981 and an MD from Johns Hopkins University School of Medicine in 1985,[3] followed by an internal medicine residency at the University of California, San Francisco.[4] He became a HHMI investigator in 2002 while at working at UCLA's Jonsson Cancer Center.[5]

Sawyers works on molecularly targeted cancer drugs, with a focus on developing a new generation of treatment options for patients. He shared the 2009 Lasker-DeBakey Clinical Medical Research Award with Brian J. Druker and Nicholas Lydon,[6] for the development of the ABL kinase inhibitor imatinib for patients with chronic myeloid leukemia and the second generation ABL inhibitor dasatinib to overcome imatinib resistance. He also co-discovered the antiandrogen drug enzalutamide that was approved by the FDA in 2012 for treatment of advanced prostate cancer.[7]

Sawyers' cancer research is discussed in the second episode of Cancer: The Emperor of All Maladies.

Significant positions

Sawyers served as President of the American Society for Clinical Investigation (ASCI) in 2007[8] and of the American Association for Cancer Research (AACR) in 2012.[9] He was also appointed to the National Cancer Advisory Board by President Obama in 2012,[10] and has served on the Board of Directors of Novartis since 2013.[11]

Memberships

Awards

References
  1. Howard Hughes Medical Institute, Annual Scientific Report, The Institute, 1990, p. 507.
  2. "At Work: Human Oncology and Pathogenesis Program Chair Charles Sawyers | Memorial Sloan Kettering Cancer Center". www.mskcc.org. Retrieved 5 April 2017.
  3. "Susan Schneck Weds Charles Sawyers". The New York Times. 22 October 1990. Retrieved 3 March 2017.
  4. "UCSF Department of Medicine Alumni Profile: Dr. Charles Sawyers". medicine.ucsf.edu. Retrieved 3 March 2017.
  5. "Charles L. Sawyers, MD". HHMI.org. Retrieved 5 April 2017.
  6. Grindlinger, Brooke; Chao, ES (1 October 2009). "Trio receives Lasker Foundation Clinical Award for breakthroughs in leukemia treatment". Journal of Clinical Investigation. 119 (10): 2863–2865. doi:10.1172/JCI41141. ISSN 0021-9738. PMC 2752112.
  7. Reyes, Antonio A.; Akeson, Richard (1988). "Generation of Multiple Independent Substitution Mutants by M13 in Vitro Mutagenesis Using a Single Mutagenic Oligonucleotide". DNA. 7 (8): 579–584. doi:10.1089/dna.1.1988.7.579. PMID 3180999.
  8. "2008 American Society of Clinical Investigation Presidential Address" (PDF). the-asci.org. Retrieved 3 March 2017.
  9. "Charles L. Sawyers, MD". aacr.org. Retrieved 4 March 2017.
  10. "President Obama Announces More Key Administration Posts". whitehouse.gov. 6 December 2012. Retrieved 4 March 2017.
  11. "Charles L. Sawyers, M.D. Member of the Board of Directors" (PDF). novartis.com. Retrieved 4 March 2017.
  12. "Doris Duke Charitable Foundation Awards $10.5 Million for Medical Research". Philanthropy News Digest (PND). Retrieved 5 April 2017.
  13. "Recipients of the David A. Karnofsky Memorial Award and Lecture - The ASCO Post". www.ascopost.com. Archived from the original on 19 September 2017. Retrieved 5 April 2017.
  14. "Awards, Appointments, Announcements". JNCI Journal of the National Cancer Institute. 97 (11): 797. 1 June 2005. doi:10.1093/jnci/97.11.797.
  15. "Dorothy P. Landon-AACR Prize for Translational Cancer Research". www.aacr.org. Retrieved 5 April 2017.
  16. Foundation, Lasker. "Molecularly targeted treatments for chronic myeloid leukemia | The Lasker Foundation". The Lasker Foundation. Retrieved 5 April 2017.
  17. "Breakthrough Prize". breakthroughprize.org. Retrieved 5 April 2017.
  18. "Taubman Prize". A. Alfred Taubman Medical Research Institute. Retrieved 16 March 2017.
  19. "2014 Honorees". The Hope Funds for Cancer Research. 5 September 2013. Retrieved 5 April 2017.
  20. "BBVA Foundation Frontiers of Knowledge Awards". www.fbbva.es. Archived from the original on 21 September 2015. Retrieved 5 April 2017.
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