Botryococcene C-methyltransferase

Botryococcene C-methyltransferase (EC 2.1.1.263, TMT-3) is an enzyme with systematic name S-adenosyl-L-methionine:botryococcene C-methyltransferase.[1] This enzyme catalyses the following chemical reaction

2 S-adenosyl-L-methionine + C30 botryococcene 2 S-adenosyl-L-homocysteine + 3,20-dimethyl-1,2,21,22-tetradehydro-2,3,20,21-tetrahydrobotryococcene (overall reaction)
(1a) S-adenosyl-L-methionine + C30 botryococcene S-adenosyl-L-homocysteine + 3-methyl-1,2-didehydro-2,3-dihydrobotryococcene
(1b) S-adenosyl-L-methionine + 3-methyl-1,2-didehydro-2,3-dihydrobotryococcene S-adenosyl-L-homocysteine + 3,20-dimethyl-1,2,21,22-tetradehydro-2,3,20,21-tetrahydrobotryococcene
(2a) S-adenosyl-L-methionine + C30 botryococcene S-adenosyl-L-homocysteine + 20-methyl-21,22-didehydro-20,21-dihydrobotryococcene
(2b) S-adenosyl-L-methionine + 20-methyl-21,22-didehydro-20,21-dihydrobotryococcene S-adenosyl-L-homocysteine + 3,20-dimethyl-1,2,21,22-tetradehydro-2,3,20,21-tetrahydrobotryococcene
Botryococcene C-methyltransferase
Identifiers
EC number2.1.1.263
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

This enzyme is isolated from the green alga Botryococcus braunii BOT22.

References
  1. Niehaus TD, Kinison S, Okada S, Yeo YS, Bell SA, Cui P, Devarenne TP, Chappell J (March 2012). "Functional identification of triterpene methyltransferases from Botryococcus braunii race B". The Journal of Biological Chemistry. 287 (11): 8163–73. doi:10.1074/jbc.m111.316059. PMC 3318757. PMID 22241476.
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