Bip internal ribosome entry site (IRES)

bip internal ribosome entry site (IRES)
	Predicted secondary structure and sequence conservation of IRES_Bip
Identifiers
Symbol	IRES_Bip
Alt. Symbols	Bip_IRES
Rfam	RF00223
Other data
RNA type	Cis-reg; IRES
Domain(s)	Eukaryota
GO	0043022
SO	0000243
PDB structures	PDBe

The BiP internal ribosome entry site (IRES) is an RNA element present in the 5' UTR of the mRNA of BiP protein and allows cap-independent translation. BiP protein expression has been found to be significantly enhanced by the heat shock response due to internal ribosome entry site (IRES)-dependent translation. It is thought that this translational mechanism is essential for the survival of cells under stress.[1]

References

Kim YK, Jang SK (September 2002). "Continuous heat shock enhances translational initiation directed by internal ribosomal entry site". Biochemical and Biophysical Research Communications. 297 (2): 224–231. doi:10.1016/S0006-291X(02)02154-X. PMID 12237106.

External links

Page for bip internal ribosome entry site (IRES) at Rfam

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[1] Kim YK, Jang SK (September 2002). "Continuous heat shock enhances translational initiation directed by internal ribosomal entry site". Biochemical and Biophysical Research Communications. 297 (2): 224–231. doi:10.1016/S0006-291X(02)02154-X. PMID 12237106.