Ben G. Davis

Education

Davis was privately educated at Nottingham High School[1] followed by the University of Oxford where he was awarded Bachelor of Arts degree in Chemistry (with Chemical Pharmacology) in 1993 and a Doctor of Philosophy in 1996 supervised by George Fleet.[15] He was a student of Keble College, Oxford.[4]

Research and career

After his PhD, Davis spent two years as a postdoctoral research fellow in the laboratory of J. Bryan Jones at the University of Toronto, exploring protein chemistry and biocatalysis.[8] In 1998 he returned to the United Kingdom to take up a lectureship at Durham University. In the autumn of 2001 he moved to the Dyson Perrins Laboratory and received a fellowship at Pembroke College, Oxford. He was promoted to Professor in 2005.[8]

His group's research centres on the chemical understanding and exploitation of biomolecular function (Synthetic Biology, Chemical Biology and Chemical Medicine), with an emphasis on carbohydrates and proteins. In particular, the group's interests encompass synthesis and methodology; target biomolecule synthesis; inhibitor/probe/substrate design; biocatalysis; enzyme and biomolecule mechanism; biosynthetic pathway determination; protein engineering; drug delivery; molecular biology; structural biology; cell biology; glycobiology; molecular imaging and in vivo biology.[8]

Research in the Davis laboratory has been funded by the Engineering and Physical Sciences Research Council, the Biotechnology and Biological Sciences Research Council, the Medical Research Council, UCB-Celltech, AstraZeneca, the European Union, GlaxoSmithKline, Cancer Research UK, the Wellcome Trust and the Royal Society.[4] He has supervised numerous postdoctoral researchers and doctoral students to completion including Bhaskar Bhushan,[16] Lukas Lercher,[17][18] Yuya Lin,[19] Mitul Patel,[20][21] Régis Saliba,[22] Samantha Shanley[23] Filip Wyszynski,[24][25] and Keisuke Yamamoto.[26][27]

Awards and honours

Davis was elected a Fellow of the Royal Society in 2015.[8] His certificate of election reads:

Professor Davis is noted for his chemical interrogation and manipulation of biological systems, particularly those that hinge on carbohydrates and proteins. He has developed selective and benign bond forming strategies that have been applied to biology, allowing the construction of synthetic biomolecules and bioconjugates; the creation of synthetic cells and viruses; and in vivo chemistry. These have enabled associated mechanistic details of protein and sugar biology to be elucidated and exploited for biotechnological applications.[9]

He was also a recipient of the Mullard Award in 2005, the Philip Leverhulme Prize in 2002 and the Meldola Medal and Prize in 1999 from the Royal Society of Chemistry.[28] In 2019, he was elected a Fellow of the Academy of Medical Sciences.[29]

References
  1. Anon (2016). "Davis, Prof. Benjamin Guy". Who's Who (online Oxford University Press ed.). A & C Black, an imprint of Bloomsbury Publishing plc. doi:10.1093/ww/9780199540884.013.283852. (subscription or UK public library membership required) (subscription required)
  2. Anon (2009). "Author profile: Benjamin G. Davis". Angewandte Chemie. 48 (22): 3900. doi:10.1002/anie.200901068.
  3. Davis, B. (2010). "Future Visions of Chemistry: Ben Davis". ChemistryViews. doi:10.1002/chemv.201000012.
  4. "The Davis Group". University of Oxford. Archived from the original on 15 June 2013.
  5. Davis, B. G. (2002). "Synthesis of glycoproteins". Chemical Reviews. 102 (2): 579–602. doi:10.1021/cr0004310. PMID 11841255.
  6. Gamblin, David P.; Scanlan, Eoin M.; Davis, Benjamin G. (2009). "Glycoprotein Synthesis: An Update". Chemical Reviews. 109 (1): 131–163. doi:10.1021/cr078291i. ISSN 0009-2665. PMID 19093879.
  7. Ambrosi, M; Cameron, N. R.; Davis, B. G. (2005). "Lectins: Tools for the molecular understanding of the glycocode". Organic and Biomolecular Chemistry. 3 (9): 1593–608. doi:10.1039/b414350g. PMID 15858635.
  8. Anon (2015). "Professor Benjamin Davis FRS". London: Royal Society. Archived from the original on 17 November 2015. One or more of the preceding sentences incorporates text from the royalsociety.org website where:
    "All text published under the heading 'Biography' on Fellow profile pages is available under Creative Commons Attribution 4.0 International License." --"Royal Society Terms, conditions and policies". Archived from the original on 25 September 2015. Retrieved 9 March 2016.CS1 maint: BOT: original-url status unknown (link)
  9. "Professor Benjamin Davis FRS". London: The Royal Society. Archived from the original on 2 May 2015.
  10. Ben G. Davis publications indexed by the Scopus bibliographic database. (subscription required)
  11. Anon (2007). "Interview with Ben Davis: Sugar Solutions". Royal Society of Chemistry. Archived from the original on 2 June 2008.
  12. Garnier, Philippe. "The Davis Group - Home". Users.ox.ac.uk.
  13. Ben G. Davis publications from Europe PubMed Central
  14. "Professor Ben Davis - Pembroke College". Pmb.ox.ac.uk. Retrieved 21 May 2018.
  15. Davis, Benjamin Guy (1996). Synthesis of inhibitors of sugar processing enzymes. jisc.ac.uk (DPhil thesis). University of Oxford. OCLC 1064614676. EThOS uk.bl.ethos.711593.
  16. Bhushan, Bhaskar (2014). Unnatural amino acids as metal-mediated probes of biological function (DPhil thesis). University of Oxford.
  17. Lercher, Lukas A. (2014). Chemical tools for the study of epigenetic mechanisms (DPhil thesis). University of Oxford. OCLC 897880623.
  18. Lercher, L; McGouran, J. F.; Kessler, B. M.; Schofield, C. J.; Davis, B. G. (2013). "DNA modification under mild conditions by Suzuki-Miyaura cross-coupling for the generation of functional probes". Angewandte Chemie International Edition. 52 (40): 10553–8. doi:10.1002/anie.201304038. PMC 3823066. PMID 23943570.
  19. Lin, Yuya Angel (2013). Olefin metathesis for site-selective protein modification (DPhil thesis). University of Oxford. OCLC 868073622.
  20. Patel, Mitul Kiran (2011). Unravelling the biological roles of charged carbohydrates (DPhil thesis). University of Oxford. OCLC 941069418.
  21. Patel, M. K.; Davis, B. G. (2010). "Flow chemistry kinetic studies reveal reaction conditions for ready access to unsymmetrical trehalose analogues". Organic & Biomolecular Chemistry. 8 (19): 4232–5. doi:10.1039/c0ob00226g. PMID 20668770.
  22. Saliba, Régis C. (2014). Design and synthesis of nanoparticles functionalised with Lewis oligosaccharides for selective targeting of DC-SIGN (DPhil thesis). University of Oxford.
  23. Shanley, Samantha Jane (2009). A glycopore for bacterial sensing (DPhil thesis). University of Oxford. OCLC 757099623.
  24. Wyszynski, Filip Jan (2010). Dissecting tunicamycin biosynthesis : a potent carbohydrate processing enzyme inhibitor. ora.ox.ac.uk (DPhil thesis). University of Oxford. OCLC 757140035. EThOS uk.bl.ethos.534182.
  25. Wyszynski, F. J.; Lee, S. S.; Yabe, T; Wang, H; Gomez-Escribano, J. P.; Bibb, M. J.; Lee, S. J.; Davies, G. J.; Davis, B. G. (2012). "Biosynthesis of the tunicamycin antibiotics proceeds via unique exo-glycal intermediates". Nature Chemistry. 4 (7): 539–46. Bibcode:2012NatCh...4..539W. doi:10.1038/nchem.1351. PMID 22717438.
  26. Yamamoto, Keisuke (2013). Modification and application of glycosidases to create homogeneous glycoconjugates (DPhil thesis). University of Oxford.
  27. Yamamoto, K; Davis, B. G. (2012). "Creation of an α-mannosynthase from a broad glycosidase scaffold". Angewandte Chemie International Edition. 51 (30): 7449–53. doi:10.1002/anie.201201081. PMID 22696205.
  28. Garnier, Philippe. "The Davis Group - Ben G. Davis". Users.ox.ac.uk. Retrieved 21 May 2018.
  29. "New Fellows: 50 top biomedical and health scientists join the Academy". Academy of Medical Sciences, United Kingdom. 8 May 2019. Retrieved 13 June 2019.

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