Apolizumab

Apolizumab is a humanized monoclonal antibody intended for use in hematologic cancers.[1][2] Development was abandoned in 2005 because of toxic effects and lack of efficacy in human patients. The observed dose limiting toxic effects were aseptic meningitis and hemolytic uremia.[3] There are no current clinical trials into its use.[4]

Apolizumab
Monoclonal antibody
TypeWhole antibody
SourceHumanized (from mouse)
TargetHLA-DR beta
Clinical data
ATC code
  • none
Identifiers
CAS Number
ChemSpider
  • none
UNII
KEGG
 NY (what is this?)  (verify)

References

  1. Bayes M; Rabasseda X; Prous J (2003). "Gateways to clinical trials". Methods Find Exp Clin Pharmacol. 25 (9): 747–71. PMID 14685303.
  2. Rech, J; Repp, R; Rech, D; Stockmeyer, B; Dechant, M; Niedobitek, G; Gramatzki, M; Valerius, T (2006). "A humanized HLA-DR antibody (hu1D10, apolizumab) in combination with granulocyte colony-stimulating factor (filgrastim) for the treatment of non-Hodgkin's lymphoma: a pilot study". Leukemia & Lymphoma. 47 (10): 2147–54. doi:10.1080/10428190600757944. PMID 17071489.
  3. Lin TS, Stock W, Xu H, Phelps MA, Lucas MS, Guster SK, Briggs BR, Cheney C, Porcu P, Flinn IW, Grever MR, Dalton JT, Byrd JC (December 2009). "A phase I/II dose escalation study of apolizumab (Hu1D10) using a stepped-up dosing schedule in patients with chronic lymphocytic leukemia and acute leukemia". Leuk. Lymphoma. 50 (12): 1958–63. doi:10.3109/10428190903186486. PMID 19860603.
  4. http://adisinsight.springer.com/drugs/800006415


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