Amine sulfotransferase
In enzymology, an amine sulfotransferase (EC 2.8.2.3) is an enzyme that catalyzes the chemical reaction
- 3'-phosphoadenylyl sulfate + an amine adenosine 3',5'-bisphosphate + a sulfamate
| amine sulfotransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 2.8.2.3 | ||||||||
| CAS number | 9026-08-8 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Thus, the two substrates of this enzyme are 3'-phosphoadenylyl sulfate and amine, whereas its two products are adenosine 3',5'-bisphosphate and sulfamate.
This enzyme belongs to the family of transferases, specifically the sulfotransferases, which transfer sulfur-containing groups. The systematic name of this enzyme class is 3'-phosphoadenylyl-sulfate:amine N-sulfotransferase. Other names in common use include arylamine sulfotransferase, and amine N-sulfotransferase. This enzyme participates in sulfur metabolism.
References
- Ramaswamy SG, Jakoby WB (1987). "Amine N-sulfotransferase". J. Biol. Chem. 262 (21): 10039–43. PMID 3475273.
- Roy, AB (1960). "The enzymic synthesis of aryl sulphamates". Biochem. J. 74: 49–56.
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