Alkylglycerophosphate 2-O-acetyltransferase
In enzymology, an alkylglycerophosphate 2-O-acetyltransferase (EC 2.3.1.105) is an enzyme that catalyzes the chemical reaction
- acetyl-CoA + 1-alkyl-sn-glycero-3-phosphate CoA + 1-alkyl-2-acetyl-sn-glycero-3-phosphate
| alkylglycerophosphate 2-O-acetyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 2.3.1.105 | ||||||||
| CAS number | 76773-96-1 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Thus, the two substrates of this enzyme are acetyl-CoA and 1-alkyl-sn-glycero-3-phosphate, whereas its two products are CoA and 1-alkyl-2-acetyl-sn-glycero-3-phosphate.
This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is acetyl-CoA:1-alkyl-sn-glycero-3-phosphate 2-O-acetyltransferase. This enzyme is also called alkyllyso-GP:acetyl-CoA acetyltransferase. This enzyme participates in ether lipid metabolism.
References
- Lee TC, Malone B, Snyder F (1986). "A new de novo pathway for the formation of 1-alkyl-2-acetyl-sn-glycerols, precursors of platelet activating factor. Biochemical characterization of 1-alkyl-2-lyso-sn-glycero-3-P:acetyl-CoA acetyltransferase in rat spleen". J. Biol. Chem. 261 (12): 5373–7. PMID 3007498.
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