Acetoacetyl-CoA synthase
Acetoacetyl-CoA synthase (EC 2.3.1.194, NphT7) is an enzyme with systematic name acetyl-CoA:malonyl-CoA C-acetyltransferase (decarboxylating).[1] This enzyme catalyses the following chemical reaction
- acetyl-CoA + malonyl-CoA acetoacetyl-CoA + CoA + CO2
| Acetoacetyl-CoA synthase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 2.3.1.194 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
The enzyme from the soil bacterium Streptomyces sp. CL190 produces acetoacetyl-CoA.
References
- Okamura E, Tomita T, Sawa R, Nishiyama M, Kuzuyama T (June 2010). "Unprecedented acetoacetyl-coenzyme A synthesizing enzyme of the thiolase superfamily involved in the mevalonate pathway". Proceedings of the National Academy of Sciences of the United States of America. 107 (25): 11265–70. doi:10.1073/pnas.1000532107. PMC 2895072. PMID 20534558.
External links
- Acetoacetyl-CoA+synthase at the US National Library of Medicine Medical Subject Headings (MeSH)
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