Abietadiene hydroxylase

Abieta-7,13-diene hydroxylase (EC 1.14.13.108) is an enzyme with systematic name abieta-7,13-diene,NADPH:oxygen oxidoreductase (18-hydroxylating).[1][2] This enzyme catalyses the following chemical reaction

abieta-7,13-diene + NADPH + H+ + O2 abieta-7,13-dien-18-ol + NADP+ + H2O
Abieta-7,13-diene hydroxylase
Identifiers
EC number1.14.13.108
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

Abietadiene hydroxylase is a heme-thiolate protein (P-450).

References

  1. Funk C, Croteau R (January 1994). "Diterpenoid resin acid biosynthesis in conifers: characterization of two cytochrome P450-dependent monooxygenases and an aldehyde dehydrogenase involved in abietic acid biosynthesis". Archives of Biochemistry and Biophysics. 308 (1): 258–66. doi:10.1006/abbi.1994.1036. PMID 8311462.
  2. Funk C, Lewinsohn E, Vogel BS, Steele CL, Croteau R (November 1994). "Regulation of Oleoresinosis in Grand Fir (Abies grandis) (Coordinate Induction of Monoterpene and Diterpene Cyclases and Two Cytochrome P450-Dependent Diterpenoid Hydroxylases by Stem Wounding)". Plant Physiology. 106 (3): 999–1005. doi:10.1104/pp.106.3.999. PMC 159624. PMID 12232380.
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