Abarelix

Abarelix, sold under the brand name Plenaxis, is an injectable gonadotropin-releasing hormone antagonist (GnRH antagonist) which is marketed in Germany and the Netherlands. It is primarily used in oncology to reduce the amount of testosterone made in patients with advanced symptomatic prostate cancer for which no other treatment options are available.[2][3]

Abarelix
Clinical data
Trade namesPlenaxis
AHFS/Drugs.comMonograph
Pregnancy
category
  • US: X (Contraindicated)
    Routes of
    administration
    Intramuscular injection
    Drug classGnRH analogue; GnRH antagonist; Antigonadotropin
    ATC code
    Pharmacokinetic data
    Protein binding96–99%
    Identifiers
    CAS Number
    PubChem CID
    IUPHAR/BPS
    DrugBank
    ChemSpider
    UNII
    KEGG
    ChEBI
    ChEMBL
    CompTox Dashboard (EPA)
    Chemical and physical data
    FormulaC72H95ClN14O14
    Molar mass1416.09 g·mol−1
    3D model (JSmol)
     NY (what is this?)  (verify)

    It was originally marketed by Praecis Pharmaceuticals as Plenaxis,[2] and is now marketed by Speciality European Pharma in Germany[4] after receiving a marketing authorization in 2005. The drug was introduced in the United States in 2003, but was discontinued in this country in May 2005 due to poor sales and a higher-than-expected incidence of severe allergic reactions.[5] It remains marketed in Germany and the Netherlands however.[6]

    See also

    References

    1. "Abarelix". PubChem. 2017-07-29.
    2. "Abarelix". Drugs.com.
    3. Boccon-Gibod L, van der Meulen E, Persson BE (June 2011). "An update on the use of gonadotropin-releasing hormone antagonists in prostate cancer". Therapeutic Advances in Urology. 3 (3): 127–40. doi:10.1177/1756287211414457. PMC 3159401. PMID 21904569.
    4. Pharmazeutische Zeitung online: Abarelix (in German)
    5. Minev B (13 January 2011). Cancer Management in Man: Chemotherapy, Biological Therapy, Hyperthermia and Supporting Measures. Springer Science & Business Media. pp. 182–. ISBN 978-90-481-9704-0.
    6. "Abarelix". Drugs.com.
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