A.N.T. Farm

The season 1 and 2 main characters of A.N.T. Farm: (from left to right) Lexi Reed, Olive Doyle, Chyna Parks, Fletcher Quimby, and Cameron Parks. Can also use cursor to identify.

• China Anne McClain as Chyna Parks, the A.N.T. program's musically gifted member who can sing, dance, and play many instruments including the guitar, piano, violin, trumpet, saxophone, flute, cello, harp, bagpipes, French horn, bugle, theremin, drums, harmonica, keyboard, bassoon, tuba, spoons, and the banjo. She is the leader of the A.N.T.s.
• Sierra McCormick as Olive Doyle, an A.N.T. with eidetic memory and great knowledge of many facts which she calls "interesting factoids."
• Jake Short as Fletcher Quimby, an A.N.T. who's an artistic genius. He has a crush on Chyna which is unrequited and non-mutual.
• Stefanie Scott as Alexis "Lexi" Reed, Chyna's biggest rival at Webster High School who is vain, self-centered, and considers herself the Queen Bee. In season 3, it is revealed that Lexi is a math prodigy.
• Carlon Jeffery as Cameron Parks (main seasons 1–2, guest star season 3), Chyna's older brother with no apparent talents unlike his sister.
• Aedin Mincks as Angus Chestnut (recurring seasons 1–2, main season 3), a computer genius A.N.T., and has an unrequited crush on Olive.

• Allie DeBerry as Paisley Houndstooth, Lexi's dimwitted best friend. She is also on the cheer squad, even though she does not know how to cheer.
• Zach Steel as Gibson (seasons 1–2), the counselor and tutor of the A.N.T. Farm, who is caring and sensitive, but also dimwitted and childlike.
• Mindy Sterling as Susan Skidmore, the principal of Webster High School, who uses the A.N.T.s' talents for her own advantage.
• Finesse Mitchell as Darryl Parks (seasons 1–3), the hopelessly stupid father of Chyna and Cameron. He loves his daughter dearly all the while neglecting Cameron.
• Christian Campos as Wacky the Wolf (seasons 1–2), the school mascot. Wacky is good friends with Chyna, Olive and Fletcher.
• Elise Neal as Roxanne Parks (season 1), the mom of Chyna and Cameron. She is a children's birthday party entertainer.
• Matt Lowe as Hippo (seasons 1–2), a man who went from the music business to the movie business to the restaurant business.
• Claire Engler as Violet (season 2), a new A.N.T. gifted in sports and athletics. She is aggressive as she has an explosive temper.
• Dominic Burgess as Zoltan Grundy (season 3), a businessman who is the CEO of Z-Tech and the its respective school.
• Zibby Allen as Madame Goo Goo, a pop celebrity, who is a parody of Lady Gaga; and Winter Maddox (season 3), Zoltan Grundy's Vice President of Acquisitions
• Piper Curda as Kennedy Van Buren / Kumiko Hashimoto (season 3), a student at Z-Tech who pretends to be Kennedy, a debate prodigy, but is actually the daughter of Mr. Hashimoto.
• Tom Choi as Mr. Hashimoto (season 3), a Japanese CEO of the Hashimoto Soda Company who first appeared in The Suite Life on Deck. He is behind the sabotage of the Z-phones.

• Zendaya as Sequoia Jones (season 1), a teen movie star who loves to play her role perfectly by shadowing a person and attempting to steal their identity.
• Vanessa Morgan as Jeanne Gossamer / Vanessa (season 2), a model from Canada and Cameron's girlfriend. Cameron misremembers her name as Jeanne Gossamer at first.
• Billy Unger as Tasmanian Neville (season 2), an Australian "explorer" who he is actually a weakling. Chyna develops a crush on Neville, which makes Fletcher jealous.
• Chris Rock as Himself (season 3), who visits the Z-Tech school to buy a rare animal for his daughter.

Disney Channel announced on November 11, 2010 that they had green-lit the show for production, which began in early 2011.[8] The show was first conceived when Dan Signer, creator of the show, saw China Anne McClain. "The girl had so much confidence. She can nail a joke. She can sing. She can play instruments. It's like China was some sort of child prodigy [...] And that's when it hit me: Why not build a show around a child prodigy? Someone who's got all of this natural talent & ability, but is still challenged when she's sent off to high school at the age of 11?" Signer said in an interview.[9] After the first few episodes of the show were shown, Disney Channel bumped up their order of episodes for the show from 13 episodes to 26 episodes for the first season.[9] On November 30, 2011, it was announced the series was renewed for a second season.[10] On October 2, 2012, it was announced the series was renewed for a third and final season.[11]

In 2009, China Anne McClain booked the starring role as Janet in the Disney Channel pilot Jack and Janet Save the Planet alongside future co-stars Sierra McCormick and Jake Short. The pilot was not picked up and never aired. After the pilot was not picked up, Dan Signer began creating another show tailor-made for McClain and cast her as the lead.[12][13][14] Sierra McCormick was cast after an audition where she continually talked about tigers. Dan Signer stated "And as I heard her continually talking about tigers, I thought 'That's just how Olive would sound,' because Olive is a fast talking, intelligent student whose talent is memory, which is how Sierra got that part." Jake Short was cast after Signer found him to be likable as an artist during his audition.[9] Jake Short was the last of the three core characters to be cast. Caroline Sunshine was originally cast as Lexi and Stefanie Scott as the role of Tinka Hessenheffer in Shake It Up!, but Dan Signer decided that Sunshine would be better as Tinka and Scott as Lexi, so the two switched roles. Sunshine, however, would later guest star in the episode "some enchANTed evening".