8-dimethylallylnaringenin 2'-hydroxylase
In enzymology, a 8-dimethylallylnaringenin 2'-hydroxylase (EC 1.14.13.103) is an enzyme that catalyzes the chemical reaction
- sophoraflavanone B + NADPH + H+ + O2 leachianone G + NADP+ + H2O
| 8-dimethylallylnaringenin 2'-hydroxylase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 1.14.13.103 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
The 4 substrates of this enzyme are sophoraflavanone B, NADPH, H+, and O2, whereas its 3 products are leachianone G, NADP+, and H2O.
This enzyme belongs to the family of oxidoreductases, specifically those acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derived from O2 with NADH or NADPH as one donor, and incorporation of one atom o oxygen into the other donor. The systematic name of this enzyme class is sophoraflavanone-B,NADPH:oxygen oxidoreductase (2'-hydroxylating). This enzyme is also called 8-DMAN 2'-hydroxylase.
References
- Yamamoto H, Yatou A, Inoue K (November 2001). "8-dimethylallylnaringenin 2'-hydroxylase, the crucial cytochrome P450 mono-oxygenase for lavandulylated flavanone formation in Sophora flavescens cultured cells". Phytochemistry. 58 (5): 671–6. doi:10.1016/S0031-9422(01)00270-9. PMID 11672730.
- Zhao P, Inoue K, Kouno I, Yamamoto H (November 2003). "Characterization of leachianone G 2"-dimethylallyltransferase, a novel prenyl side-chain elongation enzyme for the formation of the lavandulyl group of sophoraflavanone G in Sophora flavescens Ait. cell suspension cultures". Plant Physiology. 133 (3): 1306–13. doi:10.1104/pp.103.025213. PMC 281625. PMID 14551337.
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