6-hydroxyhexanoate dehydrogenase

In enzymology, a 6-hydroxyhexanoate dehydrogenase (EC 1.1.1.258) is an enzyme that catalyzes the chemical reaction

6-hydroxyhexanoate + NAD+ 6-oxohexanoate + NADH + H+
6-hydroxyhexanoate dehydrogenase
Identifiers
EC number1.1.1.258
CAS number77000-03-4
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

Thus, the two substrates of this enzyme are 6-hydroxyhexanoate and NAD+, whereas its 3 products are 6-oxohexanoate, NADH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 6-hydroxyhexanoate:NAD+ oxidoreductase. This enzyme participates in caprolactam degradation.

References

    • Donoghue NA, Trudgill PW (1975). "The metabolism of cyclohexanol by Acinetobacter NCIB 9871". Eur. J. Biochem. 60 (1): 1–7. doi:10.1111/j.1432-1033.1975.tb20968.x. PMID 1261.
    • Hecker LI, Tondeur Y, Farrelly JG (1984). "Formation of epsilon-hydroxycaproate and epsilon-aminocaproate from N-nitrosohexamethyleneimine: evidence that microsomal alpha-hydroxylation of cyclic nitrosamines may not always involve the insertion of molecular oxygen into the substrate". Chem. Biol. Interact. 49 (1–2): 235–48. doi:10.1016/0009-2797(84)90064-4. PMID 6722936.


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