5-methyltetrahydrosarcinapterin:corrinoid/iron-sulfur protein Co-methyltransferase

5-methyltetrahydrosarcinapterin:corrinoid/iron-sulfur protein Co-methyltransferase (EC 2.1.1.245, cdhD (gene), cdhE (gene)) is an enzyme with systematic name 5-methyltetrahydrosarcinapterin:corrinoid/iron-sulfur protein methyltransferase.[1][2] This enzyme catalyses the following chemical reaction:

[methyl-Co(III) corrinoid Fe-S protein] + tetrahydrosarcinapterin [Co(I) corrinoid Fe-S protein] + 5-methyltetrahydrosarcinapterin
5-methyltetrahydrosarcinapterin:corrinoid/iron-sulfur protein Co-methyltransferase
Identifiers
EC number2.1.1.245
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

This enzyme catalyses the transfer of a methyl group from the cobamide cofactor of a corrinoid/Fe-S protein to the N5 group of tetrahydrosarcinapterin.

References

  1. Maupin-Furlow J, Ferry JG (January 1996). "Characterization of the cdhD and cdhE genes encoding subunits of the corrinoid/iron-sulfur enzyme of the CO dehydrogenase complex from Methanosarcina thermophila". Journal of Bacteriology. 178 (2): 340–6. PMC 177663. PMID 8550451.
  2. Grahame DA, DeMoll E (April 1996). "Partial reactions catalyzed by protein components of the acetyl-CoA decarbonylase synthase enzyme complex from Methanosarcina barkeri". The Journal of Biological Chemistry. 271 (14): 8352–8. doi:10.1074/jbc.271.14.8352. PMID 8626532.
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