4-phosphoerythronate dehydrogenase
In enzymology, a 4-phosphoerythronate dehydogenase (EC 1.1.1.290) is an enzyme that catalyzes the chemical reaction
- 4-phospho-D-erythronate + NAD+ (3R)-3-hydroxy-2-oxo-4-phosphonooxybutanoate + NADH + H+
| 4-phosphoerythronate dehydrogenase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 1.1.1.290 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Thus, the two substrates of this enzyme are 4-phospho-D-erythronate and NAD+, whereas its 3 products are (3R)-3-hydroxy-2-oxo-4-phosphonooxybutanoate, NADH, and H+.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 4-phospho-D-erythronate:NAD+ 2-oxidoreductase. Other names in common use include PdxB, PdxB 4PE dehydrogenase, and 4-O-phosphoerythronate dehydrogenase. This enzyme participates in vitamin B6 metabolism.
Structural studies
As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 2O4C.
References
- Lam HM, Winkler ME (1990). "Metabolic relationships between pyridoxine (vitamin B6) and serine biosynthesis in Escherichia coli K-12". J. Bacteriol. 172 (11): 6518–28. PMC 526841. PMID 2121717.
- Pease AJ, Roa BR, Luo W, Winkler ME (2002). "Positive growth rate-dependent regulation of the pdxA, ksgA, and pdxB genes of Escherichia coli K-12". J. Bacteriol. 184 (5): 1359–69. doi:10.1128/JB.184.5.1359-1369.2002. PMC 134838. PMID 11844765.
- Zhao G, Winkler ME (1996). "A novel alpha-ketoglutarate reductase activity of the serA-encoded 3-phosphoglycerate dehydrogenase of Escherichia coli K-12 and its possible implications for human 2-hydroxyglutaric aciduria". J. Bacteriol. 178 (1): 232–9. PMC 177644. PMID 8550422.
- Grant GA (1989). "A new family of 2-hydroxyacid dehydrogenases". Biochem. Biophys. Res. Commun. 165 (3): 1371–4. doi:10.1016/0006-291X(89)92755-1. PMID 2692566.
- Schoenlein PV, Roa BB, Winkler ME (1989). "Divergent transcription of pdxB and homology between the pdxB and serA gene products in Escherichia coli K-12". J. Bacteriol. 171 (11): 6084–92. PMC 210475. PMID 2681152.