4-hydroxymuconic-semialdehyde dehydrogenase
In enzymology, a 4-hydroxymuconic-semialdehyde dehydrogenase (EC 1.2.1.61) is an enzyme that catalyzes the chemical reaction
- 4-hydroxymuconic semialdehyde + NAD+ + H2O maleylacetate + NADH + 2 H+
| 4-hydroxymuconic-semialdehyde dehydrogenase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 1.2.1.61 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
The 3 substrates of this enzyme are 4-hydroxymuconic semialdehyde, NAD+, and H2O, whereas its 3 products are maleylacetate, NADH, and H+.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 4-hydroxymuconic-semialdehyde:NAD+ oxidoreductase. This enzyme participates in gamma-hexachlorocyclohexane degradation.
References
- Spain JC, Gibson DT (1991). "Pathway for Biodegradation of p-Nitrophenol in a Moraxella sp". Appl. Environ. Microbiol. 57 (3): 812–819. PMC 182799. PMID 16348446.
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