4-(hydroxymethyl)benzenesulfonate dehydrogenase

In enzymology, a 4-(hydroxymethyl)benzenesulfonate dehydrogenase (EC 1.1.1.257) is an enzyme that catalyzes the chemical reaction

4-(hydroxymethyl)benzenesulfonate + NAD+ 4-formylbenzenesulfonate + NADH + H+
4-(hydroxymethyl)benzene-sulfonate dehydrogenase
Identifiers
EC number1.1.1.257
CAS number167973-64-0
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

Thus, the two substrates of this enzyme are 4-(hydroxymethyl)benzenesulfonate and NAD+, whereas its 3 products are 4-formylbenzenesulfonate, NADH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 4-(hydroxymethyl)benzenesulfonate:NAD+ oxidoreductase. This enzyme participates in 2,4-dichlorobenzoate degradation.

References

    • Junker F, Saller E, Schläfli Oppenberg HR, Kroneck PM, Leisinger T, Cook AM (September 1996). "Degradative pathways for p-toluenecarboxylate and p-toluenesulfonate and their multicomponent oxygenases in Comamonas testosteroni strains PSB-4 and T-2". Microbiology. 142 ( Pt 9) (9): 2419–27. doi:10.1099/00221287-142-9-2419. PMID 8828208.


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