3-oxoacyl-(acyl-carrier-protein) reductase (NADH)
In enzymology, a 3-oxoacyl-[acyl-carrier-protein] reductase (NADH) (EC 1.1.1.212) is an enzyme that catalyzes the chemical reaction
- (3R)-3-hydroxyacyl-[acyl-carrier-protein] + NAD+ 3-oxoacyl-[acyl-carrier-protein] + NADH + H+
| 3-oxoacyl-[acyl-carrier-protein] reductase (NADH) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 1.1.1.212 | ||||||||
| CAS number | 82047-86-7 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Thus, the two substrates of this enzyme are [[(3R)-3-hydroxyacyl-[acyl-carrier-protein]]] and NAD+, whereas its 3 products are [[3-oxoacyl-[acyl-carrier-protein]]], NADH, and H+.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (3R)-3-hydroxyacyl-[acyl-carrier-protein]:NAD+ oxidoreductase. Other names in common use include 3-oxoacyl-[acyl carrier protein] (reduced nicotinamide adenine, dinucleotide) reductase, and 3-oxoacyl-[acyl-carrier-protein] reductase (NADH).
References
- Caughey I, Kekwick RG (1982). "The characteristics of some components of the fatty acid synthetase system in the plastids from the mesocarp of avocado (Persea americana) fruit". Eur. J. Biochem. 123 (3): 553–61. doi:10.1111/j.1432-1033.1982.tb06568.x. PMID 7075600.
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