3'-demethylstaurosporine O-methyltransferase

In enzymology, a 3'-demethylstaurosporine O-methyltransferase (EC 2.1.1.139) is an enzyme that catalyzes the chemical reaction

S-adenosyl-L-methionine + 3'-demethylstaurosporine S-adenosyl-L-homocysteine + staurosporine
3'-demethylstaurosporine O-methyltransferase
Identifiers
EC number2.1.1.139
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

Thus, the two substrates of this enzyme are S-adenosyl methionine and 3'-demethylstaurosporine, whereas its two products are S-adenosylhomocysteine and staurosporine.

This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:3'-demethylstaurosporine O-methyltransferase. Other names in common use include 3'-demethoxy-3'-hydroxystaurosporine O-methyltransferase, and staurosporine synthase.

References

    • Weidner S, Kittelmann M, Goeke K, Ghisalba O, Zähner H (July 1998). "3'-Demethoxy-3'-hydroxystaurosporine-O-methyltransferase from Streptomyces longisporoflavus catalyzing the last step in the biosynthesis of staurosporine". The Journal of Antibiotics. 51 (7): 679–82. doi:10.7164/antibiotics.51.679. PMID 9727395.


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