23S rRNA pseudouridine2604 synthase

23S rRNA pseudouridine2604 synthase (EC 5.4.99.21, RluF, YjbC) is an enzyme with systematic name 23S rRNA-uridine2604 uracil mutase.[1][2][3] This enzyme catalyses the following chemical reaction

23S rRNA uridine2604 23S rRNA pseudouridine2604
23S rRNA pseudouridine2604 synthase
Identifiers
EC number5.4.99.21
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

The enzyme can, to a small extent, also react with uridine2605.

References

  1. Del Campo M, Kaya Y, Ofengand J (November 2001). "Identification and site of action of the remaining four putative pseudouridine synthases in Escherichia coli". RNA. 7 (11): 1603–15. PMC 1370202. PMID 11720289.
  2. Alian A, DeGiovanni A, Griner SL, Finer-Moore JS, Stroud RM (May 2009). "Crystal structure of an RluF-RNA complex: a base-pair rearrangement is the key to selectivity of RluF for U2604 of the ribosome". Journal of Molecular Biology. 388 (4): 785–800. doi:10.1016/j.jmb.2009.03.029. PMC 2796871. PMID 19298824.
  3. Sunita S, Zhenxing H, Swaathi J, Cygler M, Matte A, Sivaraman J (June 2006). "Domain organization and crystal structure of the catalytic domain of E.coli RluF, a pseudouridine synthase that acts on 23S rRNA". Journal of Molecular Biology. 359 (4): 998–1009. doi:10.1016/j.jmb.2006.04.019. PMID 16712869.
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