23S rRNA (guanosine2251-2'-O)-methyltransferase
23S rRNA (guanosine2251-2'-O)-methyltransferase (EC 2.1.1.185, rlmB (gene), yifH (gene)) is an enzyme with systematic name S-adenosyl-L-methionine:23S rRNA (guanosine2251-2'-O-)-methyltransferase.[1][2] This enzyme catalyses the following chemical reaction
- S-adenosyl-L-methionine + guanosine2251 in 23S rRNA S-adenosyl-L-homocysteine + 2'-O-methylguanosine2251 in 23S rRNA
| 23S rRNA (guanosine2251-2'-O)-methyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 2.1.1.185 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
The enzyme catalyses the methylation of guanosine2251.
References
- Lövgren JM, Wikström PM (December 2001). "The rlmB gene is essential for formation of Gm2251 in 23S rRNA but not for ribosome maturation in Escherichia coli". Journal of Bacteriology. 183 (23): 6957–60. doi:10.1128/jb.183.23.6957-6960.2001. PMC 95539. PMID 11698387.
- Michel G, Sauvé V, Larocque R, Li Y, Matte A, Cygler M (October 2002). "The structure of the RlmB 23S rRNA methyltransferase reveals a new methyltransferase fold with a unique knot". Structure. 10 (10): 1303–15. doi:10.1016/s0969-2126(02)00852-3. PMID 12377117.
External links
- 23S+rRNA+(guanosine2251-2'-O)-methyltransferase at the US National Library of Medicine Medical Subject Headings (MeSH)
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