23S rRNA (guanine2445-N2)-methyltransferase

23S rRNA (guanine2445-N2)-methyltransferase (EC 2.1.1.173, ycbY (gene), rlmL (gene)) is an enzyme with systematic name S-adenosyl-L-methionine:23S rRNA (guanine2445-N2)-methyltransferase.[1] This enzyme catalyses the following chemical reaction

S-adenosyl-L-methionine + guanine2445 in 23S rRNA S-adenosyl-L-homocysteine + N2-methylguanine2445 in 23S rRNA
23S rRNA (guanine2445-N2)-methyltransferase
Identifiers
EC number2.1.1.173
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

The enzyme methylates 23S rRNA in vitro.

References

  1. Lesnyak DV, Sergiev PV, Bogdanov AA, Dontsova OA (November 2006). "Identification of Escherichia coli m2G methyltransferases: I. the ycbY gene encodes a methyltransferase specific for G2445 of the 23 S rRNA". Journal of Molecular Biology. 364 (1): 20–5. doi:10.1016/j.jmb.2006.09.009. PMID 17010378.
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