23S rRNA (adenine2503-C2,C8)-dimethyltransferase
23S rRNA (adenine2503-C2,C8)-dimethyltransferase (EC 2.1.1.194, Cfr, Cfr methyltransferase, Cfr rRNA methyltransferase) is an enzyme with systematic name S-adenosyl-L-methionine:23S rRNA (adenine2503-C2,C8)-dimethyltransferase.[1][2][3] This enzyme catalyses the following chemical reaction
- 2 S-adenosyl-L-methionine + adenine2503 in 23S rRNA 2 S-adenosyl-L-homocysteine + 2,8-dimethyladenine2503 in 23S rRNA
| 23S rRNA (adenine2503-C2,C8)-dimethyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 2.1.1.194 | ||||||||
| CAS number | 39369-30-7 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
This enzyme contains an [4Fe-S] cluster.
References
- Yan F, LaMarre JM, Röhrich R, Wiesner J, Jomaa H, Mankin AS, Fujimori DG (March 2010). "RlmN and Cfr are radical SAM enzymes involved in methylation of ribosomal RNA". Journal of the American Chemical Society. 132 (11): 3953–64. doi:10.1021/ja910850y. PMC 2859901. PMID 20184321.
- Giessing AM, Jensen SS, Rasmussen A, Hansen LH, Gondela A, Long K, Vester B, Kirpekar F (February 2009). "Identification of 8-methyladenosine as the modification catalyzed by the radical SAM methyltransferase Cfr that confers antibiotic resistance in bacteria". RNA. 15 (2): 327–36. doi:10.1261/rna.1371409. PMC 2648713. PMID 19144912.
- Kaminska KH, Purta E, Hansen LH, Bujnicki JM, Vester B, Long KS (March 2010). "Insights into the structure, function and evolution of the radical-SAM 23S rRNA methyltransferase Cfr that confers antibiotic resistance in bacteria". Nucleic Acids Research. 38 (5): 1652–63. doi:10.1093/nar/gkp1142. PMC 2836569. PMID 20007606.
External links
- 23S+rRNA+(adenine2503-C2,C8)-dimethyltransferase at the US National Library of Medicine Medical Subject Headings (MeSH)
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