2-hydroxy-4-carboxymuconate semialdehyde hemiacetal dehydrogenase

2-hydroxy-4-carboxymuconate semialdehyde hemiacetal dehydrogenase (EC 1.1.1.312, 2-hydroxy-4-carboxymuconate 6-semialdehyde dehydrogenase, 4-carboxy-2-hydroxy-cis,cis-muconate-6-semialdehyde:NADP+ oxidoreductase, alpha-hydroxy-gamma-carboxymuconic epsilon-semialdehyde dehydrogenase, 4-carboxy-2-hydroxymuconate-6-semialdehyde dehydrogenase, LigC, ProD) is an enzyme with systematic name 4-carboxy-2-hydroxymuconate semialdehyde hemiacetal:NADP+ 2-oxidoreductase.[1][2][3][4] This enzyme catalyses the following chemical reaction

4-carboxy-2-hydroxymuconate semialdehyde hemiacetal + NADP+ 2-oxo-2H-pyran-4,6-dicarboxylate + NADPH + H+
2-hydroxy-4-carboxymuconate semialdehyde hemiacetal dehydrogenase
Identifiers
EC number1.1.1.312
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

Unsubstituted aliphatic or aromatic aldehydes or glucose cannot serve as substrate of this enzyme.

References
  1. Maruyama K, Ariga N, Tsuda M, Deguchi K (April 1978). "Purification and properties of alpha-hydroxy-gamma-carboxymuconic epsilon-semialdehyde dehydrogenase". Journal of Biochemistry. 83 (4): 1125–34. PMID 26671.
  2. Maruyama K (December 1979). "Isolation and identification of the reaction product of alpha-hydroxy-gamma-carboxymuconic epsilon-semialdehyde dehydrogenase". Journal of Biochemistry. 86 (6): 1671–7. PMID 528534.
  3. Maruyama K (February 1983). "Purification and properties of 2-pyrone-4,6-dicarboxylate hydrolase". Journal of Biochemistry. 93 (2): 557–65. PMID 6841353.
  4. Masai E, Momose K, Hara H, Nishikawa S, Katayama Y, Fukuda M (December 2000). "Genetic and biochemical characterization of 4-carboxy-2-hydroxymuconate-6-semialdehyde dehydrogenase and its role in the protocatechuate 4,5-cleavage pathway in Sphingomonas paucimobilis SYK-6". Journal of Bacteriology. 182 (23): 6651–8. doi:10.1128/jb.182.23.6651-6658.2000. PMC 111406. PMID 11073908.
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