2-alkyn-1-ol dehydrogenase
In enzymology, a 2-alkyn-1-ol dehydrogenase (EC 1.1.1.165) is an enzyme that catalyzes the chemical reaction
- 2-butyne-1,4-diol + NAD+ 4-hydroxy-2-butynal + NADH + H+
| 2-alkyn-1-ol dehydrogenase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 1.1.1.165 | ||||||||
| CAS number | 54576-94-2 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Thus, the two substrates of this enzyme are 2-butyne-1,4-diol and NAD+, whereas its 3 products are 4-hydroxy-2-butynal, NADH, and H+.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 2-butyne-1,4-diol:NAD+ 1-oxidoreductase.
References
- Miyoshi T, Sato H, Harada T (1974). "Purification and characterization of 2-alkyne-1-ol dehydrogenase induced by 2-butene-1,4-diol in Fusarium merismoides B11". Biochim. Biophys. Acta. 358: 231–239. doi:10.1016/0005-2744(74)90452-5.
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