2-Deoxy-scyllo-inosamine dehydrogenase

2-deoxy-scyllo-inosamine dehydrogenase (EC 1.1.1.329, neoA (gene name), kanK (gene name)) is an enzyme with systematic name 2-deoxy-scyllo-inosamine:NAD(P)+ 1-oxidoreductase.[1][2] This enzyme catalyses the following chemical reaction

2-deoxy-scyllo-inosamine + NAD(P)+ 3-amino-2,3-dideoxy-scyllo-inosose + NAD(P)H + H+
2-deoxy-scyllo-inosamine dehydrogenase
Identifiers
EC number1.1.1.329
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

This enzyme requires zinc.

References

  1. Kudo F, Yamamoto Y, Yokoyama K, Eguchi T, Kakinuma K (December 2005). "Biosynthesis of 2-deoxystreptamine by three crucial enzymes in Streptomyces fradiae NBRC 12773". The Journal of Antibiotics. 58 (12): 766–74. doi:10.1038/ja.2005.104. PMID 16506694.
  2. Nepal KK, Oh TJ, Sohng JK (May 2009). "Heterologous production of paromamine in Streptomyces lividans TK24 using kanamycin biosynthetic genes from Streptomyces kanamyceticus ATCC12853". Molecules and Cells. 27 (5): 601–8. doi:10.1007/s10059-009-0080-5. PMID 19466609.
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